Goal 2: Reduce Human Disease

What do we know about Heart Failure with Preserved Ejection Fraction (HFpEF)

Mortality is similar between HFpEF and HFrEF but we have currently no viable therapeutic option for HFpEF. There have been many large trials, but they all failed. Our basic understanding of the disease is very limited which contributed to failures of many prior trials and wasting $$$. We know very little about the pathophysiology of the disease . It is time to get back to the basic science and use our new tools (e.g. imaging, genetics, physiology, etc) to gain mechanistic understanding of the disease to enable us developing effective therapies for this disease.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Better therapy for HFpEF is an unmet clinical needs which will impact millions of patients

Tags (Keywords associated with the idea)



6 net votes
17 up votes
11 down votes
Idea No. 114