Showing 6 ideas for tag "analysis"
(@teitelbaum) kudos icon +

Goal 4: Develop Workforce and Resources

Credible Data and Analysis of the Biomedical Research Workforce

There is a need for sensible policies that require collection and scientific analysis of credible data relating to the biomedical workforce. The data currently available are weak – for example no one knows, to a factor of 2X, the actual number of postdocs in the United States. The absence of credible human resource and labor market data on the biomedical research workforce is very surprising. NIH could contribute greatly... more »

Voting

6 net votes
15 up votes
9 down votes
Active
(@rao000) kudos icon +

Goal 3: Advance Translational Research

Advancing translational research requires timely in-depth analysis of large datasets

1. NHLBI investments over the last decade in terms of genomic approaches have yielded many research findings.
2. Rapid analyses of early data identified the "low hanging" fruit (and perhaps some/many important results were missed); this limited the scope of translation (partly because of relatively limited discovery?)
3. Important data are being generated at much greater rate than the data are processed/analyzed thoughtfully.... more »

Voting

1 net vote
11 up votes
10 down votes
Active
(@jinsongzhang8012) kudos icon +

Goal 2: Reduce Human Disease

Develop and apply single-cell-based assays to verify/modify existing biological theories

Many biological models developed to date are based on studies using heterogeneous cell populations. For example, ChIP-Seq studies have shown that RNA Pol II is frequently paused near promotes and that in stem cells, developmentally poised genes are controlled by bivalent enhancers. These studies are largely based on statistical analyses of average ChIP-Seq reads from millions of cells. Earlier biochemical analysis of... more »

Voting

0 net votes
2 up votes
2 down votes
Active
(@nhlbiforumadministrator) kudos icon +

Goal 3: Advance Translational Research

Point of care detection of rare cells in blood

Laboratory analyses at the bedside or in the hinterlands can reduce the cost and increase the capture of disease states in underserved populations. The injection of a blood draw directly into a portable device that requires no further operator interventions is a Critical Challenge. With today’s automated chemistry and a miniaturized flow cytometer this challenge could be met.

Voting

-6 net votes
4 up votes
10 down votes
Active