Showing 3 ideas for tag "cad"

Goal 2: Reduce Human Disease

Non-obstructive Coronary Disease

It is increasingly apparent that ischemic heart disease does not equal obstructive coronary disease. There is a large, heterogeneous population of individuals who present to the ED with chest pain syndrome with or without a troponin elevation, who on diagnostic evaluation have non-obstructive disease and who on prospective studies have increased risk for ACS and early mortality; other literature shows the same for coronary... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

Patients with non-obstructive coronary disease represent a large proportion of patients who report to the ED with chest pain of cardiac origin. This hetergeneous group of patients have elevated ACS/mortality risk, yet little is known of the underlying pathophysiology or of the precipitants of chest pain and events. Research focused on characterizing distinct patient groups and associated pathways by which environmental factors precipitate chest pain and events would provide enormous benefit in the development and targeting of interventions to improve patient outcomes and reduce risk of catastrophic cardiac events.

Feasibility and challenges of addressing this CQ or CC

The challenges include assembling a sufficiently large patient sample to characterize distinct phenotypes. The technologies for this characterization are sufficiently disseminated to accomplish this. Furthermore, the technologies for ascertaining key elements of pathophysiology - e.g., vascular, autonomic - are also widely available. The recent expansion of technologies for ecological measurement of environmental factors and of physiological phenomena make this a feasible undertaking at this time

Name of idea submitter and other team members who worked on this idea Matthew Burg, PhD

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52 up votes
18 down votes
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Goal 3: Advance Translational Research

The effectiveness of a protocol-based screening in treating common COPD comorbidities

Does a protocol-based screening for commonly occurring comorbid conditions in patients with COPD (eg. CAD, CHF, depression, sleep apnea) improve management and outcomes for patients with COPD?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Many times co- morbidities are not address appropriately in patients with COPD- a protocol- based screening would support better identification and adherence to guidelines and would improve management and outcomes of individuals with COPD>

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15 up votes
2 down votes
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Goal 2: Reduce Human Disease

How do comorbidity of SDB, ED,(and others?) in sleep indicate or predict CAD?

CQ

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Can be early warnings

Feasibility and challenges of addressing this CQ or CC

Easy to measure and assess

Name of idea submitter and other team members who worked on this idea D. Davis

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1 net vote
1 up votes
0 down votes
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