Showing 9 ideas for tag "comorbidities"

Goal 2: Reduce Human Disease

Optimize treatment strategies for cardiovascular diseases by considering comorbid conditions

Patients seen by doctors often relay a specific health issue and are treated for that particular complaint using a standard list of treatment regimens that do not consider comorbid conditions as a significant beneficial means to optimize positive outcomes. Other than allergy considerations, immediate cost often appears to drive treatments.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

Treatment of prevalent cardiovascular diseases such as hypertension, heart failure, or COPD can require multiple interventions and still fail to ameliorate the deleterious condition. If treatments were better considered in light of other common comorbidites such as depression, inflammation, metabolic syndrome/diabetes, oxidative stress, life issues, or sleep issues, the chances of favorable outcomes of treatments are likely to improve.

Feasibility and challenges of addressing this CQ or CC

We know that cardiovascular diseases arise form multiple causes and are likely exacerbated by comorbid conditions, yet standard care for these conditions is often based on cost or habit of treating physician attending to the particular primary complaint. Proper consideration of the patient as a whole has become increasingly rare, perhaps due to time issues or use of differential diagnosis to treat the most common probable condition. Both animal models and human subject data would be very useful for optimizing treatments for cardiovascular diseases based on comorbid conditions. In addition, further investigation of yet unidentified potential comorbid factors are needed. This approach combined with consideration of genetic risk factors when appropriate could significantly improve quality of life and ultimately reduce health care costs.

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18 net votes
28 up votes
10 down votes
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Goal 3: Advance Translational Research

The effectiveness of a protocol-based screening in treating common COPD comorbidities

Does a protocol-based screening for commonly occurring comorbid conditions in patients with COPD (eg. CAD, CHF, depression, sleep apnea) improve management and outcomes for patients with COPD?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Many times co- morbidities are not address appropriately in patients with COPD- a protocol- based screening would support better identification and adherence to guidelines and would improve management and outcomes of individuals with COPD>

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13 net votes
15 up votes
2 down votes
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Goal 3: Advance Translational Research

Guideline effectiveness in treating COPD patients with comorbidities vs. those without

What is the effectiveness of guideline recommendations for chronic obstructive pulmonary disease (COPD) care in patients with multimorbidity, including angina, heart failure, atrial fibrillation, diabetes mellitus, hypertension, and osteoporosis, vs. patients without these conditions?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

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11 net votes
15 up votes
4 down votes
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Goal 3: Advance Translational Research

Coordination of COPD care when comorbidities are present

How should providers coordinate management strategies and treatment goals in patients with COPD and other co-existing chronic diseases?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea Janice Cotton, COPD Foundation State Captain for IL, PPRN Governing Board Member

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11 net votes
12 up votes
1 down votes
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Goal 3: Advance Translational Research

Integrated Clinical Guideline on Comorbidities in Primary Care

The development of systematic evidence reviews (SER) that provide the evidence that partner organizations can use to develop an integrated clinical practice guideline for use by primary care providers for the treatment of patients with single and multiple conditions for the primary and secondary prevention of heart, lung, blood, and sleep (heart, lung, blood, sleep) diseases.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

• Despite the success of single condition/disease guidelines, patients often have multiple conditions/risk factors that interact in various ways and can accelerate the development of atherosclerosis and chronic lung diseases. Effective management therefore requires a more integrated approach to assessment and treatment that spans all of relevant risk factors and conditions.
• The development of an integrated guideline has been recommended by participants in several NHLBI forums, including the NHLBI Strategic Planning process, the NHLBI Conference to Create a Cardiovascular Knowledge Network, and the Cardiovascular Disease Thought Leaders Meeting.

Feasibility and challenges of addressing this CQ or CC

Feasibility: • NHLBI currently participates with other Institutes in funding research on comorbidities, Behavioral Interventions to Address Multiple Chronic Health Conditions in Primary Care (R01, PA-12-024).
• An increasing number of scholarly articles are addressing the magnitude and cost of the problem and calling for guidelines that address this reality.

Challenges: .

• Few studies have focused on the management of patients with multiple chronic conditions.

• Clinical research often excludes persons with multiple chronic conditions.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

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1 net vote
12 up votes
11 down votes
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Goal 2: Reduce Human Disease

Incorporate important co-morbidities of COPD into treatment guidelines

Incorporate important co-morbidities of COPD into treatment guidelines. This becomes crucially important with cardiovascular disease (CVD) which shares risk factors and pathogenesis

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea American Thoracic Society member

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2 net votes
2 up votes
0 down votes
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Goal 2: Reduce Human Disease

Management of COPD in the presence of comorbidity

Management of COPD in the presence of comorbidity

• Does a protocol-based screening for commonly occurring comorbid conditions in patients with COPD (eg. CAD, CHF, depression, sleep apnea) improve management and outcomes for patients with COPD?

• How should providers coordinate management strategies and treatment goals in patients with COPD and other co-existing chronic diseases?

• What is the comparative effectiveness... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea American Thoracic Society member

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1 net vote
1 up votes
0 down votes
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Goal 2: Reduce Human Disease

Systemic manifestations and co‐morbidities of chronic lung disease

More emphasis must be placed on systemic manifestations and co‐morbidities of chronic lung disease such as depression, oral disease and heart disease.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

Management of multiple comorbidities: Health care delivery is undergoing reform to improve
efficiency and reduce costs. At present subspecialists are generally adept at managing a narrow aspect
of an individual’s health but less commonly is a practitioner able to provide comprehensive
management of people with multiple comorbidities. Indeed, many clinical trials are performed in highly
selected cohorts yielding important results but frequently lacking the generalizability to be applied to
many of our patients. Thus, we would support efforts to optimize the design of clinical trials to be more
applicable to heterogeneous groups including elderly, people with chronic diseases, and patients
receiving multiple medications.

Name of idea submitter and other team members who worked on this idea Research Advocacy Committee, American Thoracic Society

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1 net vote
1 up votes
0 down votes
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Goal 3: Advance Translational Research

Factors affecting ischemia and reperfusion

What is the impact of age, gender, and comorbidities on pathophysiology and treatment of total body ischemia and reperfusion, and how should therapies be modified accordingly?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea AHA Staff & Volunteers

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-1 net votes
2 up votes
3 down votes
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