Showing 10 ideas for tag "epigenetics"
(@ryanr0) kudos icon +

Goal 1: Promote Human Health

Developmental Origins of Adult Lung, Heart and Blood Disease

It all starts in childhood. Yet it is difficult to find funding to really study these questions because the follow up timeline is long and thus very expensive but critically important. We don't even know what the "right" way to feed infants is in the first year of life to both limit cardiometabolic syndrome but also preserve neurodevelopmental outcome. We also have just started to see the tii of the iceberg in understanding... more »


22 net votes
41 up votes
19 down votes
(@gko000) kudos icon +

Goal 2: Reduce Human Disease

Role of epigenetic mechanisms in cardiovascular disease

Are epigenetic changes the cause or the consequence of changes in cell function that contribute to cardiovascular disease?

If they are the cause, what are the mechanisms that lead to changes and how do they impact disease pathogenesis?

If the consequence, do they play any role in disease pathogenesis?

What methods can be used to test if epigenetic changes play a causal role in disease pathogenesis? Thus far studies... more »


21 net votes
28 up votes
7 down votes
(@stacey.rentschler) kudos icon +

Goal 3: Advance Translational Research

Translational Cardiovascular Medicine

There is a need for the NHLBI to catalyze the development of tools and shared data resources to facilitate mechanistic studies in a human model system. This includes the ability to culture human cardiac tissue, as well as generate a resource to systematically characterize and catalog the epigenome and histone marks associated with the transcriptome in normal and diseased heart tissues.


6 net votes
10 up votes
4 down votes