What are the best strategies to improve implementation of evidence-based practices (EBP) to enhance effective health risk communication strategies among racial and ethnic minority males and underserved men?
Examples of several issues that need to be addressed are:
• Need for better definition of the role of families/communities in EBP (as co-therapists).
• Requires less system fragmentation
• Need for improved measurement,... more »

What are the best, evidence-based models to facilitate holistic care across the lifespan for individuals living with sickle cell?

What are the best implementation strategies to improve adherence to clinical practice guidelines, protocols, and other evidence-based practices that actually lead to the elimination of inequities in preventable disability and death from heart, lung, blood, and sleep diseases?

What are the best ways for the NHLBI to advance the evolving science of translating robust evidence into clinical practice domestically and globally? How to personalize broad research evidence for individual patients?
How to predict and evaluate the impact of evidence-based interventions?
How to identify implementation methods available in industry and elsewhere that work best and are most translatable in healthcare?... more »

How do we better understand patient and provider behaviors, as well as health system, community, and socio-cultural factors to effectively address the barriers to the development, adoption of, and adherence to evidence based practices?

How can we most efficiently utilize limited resources/manpower to facilitate adherence to evidence-based practices and enhance public health?

How do we harness the ongoing “natural experiments” of quality improvement (QI) activities in various healthcare systems to facilitate hypothesis-driven research, improve scientific validity to address questions in clinical trials, and implement and disseminate research results?

• Current restrictions in human subjects research regulations
• Diversity in approaches and methodology rigor to QI initiatives across different... more »

Multiple factors contribute to the high mortality from heart and vascular diseases in our population, most prominently genetics, patient behavior, care access, and care quality. Historically, interventions have targeted patient behaviors. Though access remains a problem, those who do receive care may not be getting the best of care based on the evidence. A focus on increasing practitioner adoption of evidence-based... more »

By integrating disease orientation and diagnostic classification (e.g., ICD-10 with time-honored treatments) with endotype analysis, will translation of evidence-based care be improved?

How can implementation strategies be tested in low and middle income countries for contextually and culturally adapted evidence-based clinical care guidelines with a focus on prevalent non-communicable diseases with large burdens such as sickle cell disease, hypertension, heart disease, stroke, asthma, and COPD?

Using previous federal and partner infrastructure, what are the best methods to promote culturally competent T4 interventions that will reduce cardiopulmonary risk factors in global populations with a disproportionate burden of heart, lung, blood, sleep diseases?