Showing 2 ideas for tag "functions"

Goal 2: Reduce Human Disease

Do we yet know all of the Resident Cellular Components of the Human Lung?

The DLD, NHLBI workshops conducted and published (Reference 1, 2, 3) had as their purpose to stimulate research that would identify still obscure or novel cellular components of the human lung to determine cell function in promoting respiratory tract development and in health that contributes to disease, so that better therapy might result. With robust technologies now available, especially genomic advances, how much... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

To completely understand how the human lung responds and reacts to inhaled or aspirated particles, microbes, and environmental antigens, etc.; then initiates innate and/or acquired adaptive immunity; or creates a milieu wherein cancerous cells that have travelled to the lung can establish metastatic sites, we must identify, characterize through special phenotyping and cellular function, and isolate for ex vivo study the still understudied and unknown properties of a sizable number of the 40 resident cell types in the human lung.

Knowledge about all the resident cells in the human lung and their functions should enhance understanding of the respiratory tract in health and disease.


  1. Needs and opportunities for research in hypersensitivity pneumonitis.
    Fink JN, et. al.
    Am J Respir Crit Care Med. 2005 April 1;171(7):792-8. Review.

  2. The mysterious pulmonary brush cell: a cell in search of a function.
    Reid L, et. al.
    Am J Respir Crit Care Med. 2005 July 1;172(7):136-9. Review.

  3. Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function.
    Franks TJ, et. al.
    Proc Am Thorac Soc. 2008 Sep 15;5(7):763-6. Doi: 10.1513/pats.200803-025HR.

Feasibility and challenges of addressing this CQ or CC

Technologies seem available.

Name of idea submitter and other team members who worked on this idea Herbert Y. Reynolds, M.D.


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