Showing 4 ideas for tag "hypothermia"

Goal 1: Promote Human Health

Hypothermia and hemostasis after severe trauma

There is a need to employ new molecular tools to delineate the difference between beneficial and uncontrolled shock-induced hypothermia, because data on hypothermia and hemostasis are incomplete or lacking, especially on the duration, depth and type of hypothermia.

 

availability of targeted resource grant funding

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

improvement of survival with life threatening traumatic injuries with new metabolically modulating strategies, including "simple hypothermia", improved understanding of the relationship between ischemia and reperfusion, the role of inflammatory and metabolic pathways, definition and identification of appropriate targets for therapy, the role for mechanical devices, and relationship between timely application of hypothermia and rewarming.

Feasibility and challenges of addressing this CQ or CC

the tools and animal models are available to study hemostatic and metabolic modulation/hypothermia in traumatic injury
Trauma is the major cause of death in young individuals in the US, and globally, with uncontrolled hemorrhage representing the major cause of preventable deaths. Hypothermia, used in life threatening cardiovascular states, also holds enormous promise for application in traumatic injuries. Early deployment (pre-hospital) of novel protective metabolically modulating strategies to attenuate cellular injury from shock and reperfusion, such as hypothermia could be beneficial. However, the relationship between hypothermia in traumatic setting is complex, with data suggesting detrimental outcomes if it occurred spontaneously. In contrast, hypothermia induced in a controlled manner can protect tissues from ischemic injury.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

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Goal 2: Reduce Human Disease

Early cardioprotection for acute MI through cooling

What is an appropriate mechanism and study design to evaluate the beneficial effects of hypothermia following acute myocardial infarction?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Acute myocardial infarction remains a major cause of morbidity and mortality. Additional therapies beyond reperfusion are required to improve outcome.

Feasibility and challenges of addressing this CQ or CC

Proof of concept has been established to support the acute effects of cooling in experimental models as well as humans.
Induction of hypothermia has proven dramatically effective in reducing myocardial infarct size in experimental models. Most studies in humans for STEMI have also shown a reduction in infarct size for subjects with anterior MIs cooled to below 35 degrees prior to reperfusion. However, long-term outcomes, including survival rates, LV remodeling, and prevention of heart failure, are unknown. Early treatment during transport to a hospital with a cardiac catheterization laboratory may be the most critical application for such a method. Ensuring trained first responders, community consent, appropriate study design, and financial support to assess long-term effects are a challenge. Simple methods of quickly and adequately ensuring consistent cooling are emerging.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

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