Showing 2 ideas for tag "lymphatic"

Goal 1: Promote Human Health

Role of the lymphatic system in heart, lung, blood, sleep health and diseases

What is the role of lymphatic system in normal function of the heart? Do dysfunctional lymphatics contribute to heart failure? Do lymphatics have a role in recovery after MI? It has been reported that lymphatic vasculature transport HDL during reverse cholesterol transfer. Do lymphatics have a role in atherosclerosis? What is the contribution of lymphatic system to asthma or COPD? Does the lymphatic system contribute... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Understanding how lymphatic system contributes to normal physiology of heart, lung, blood, sleep systems will help also lead to new approaches for treatment of heart, lung, blood, sleep diseases.

Feasibility and challenges of addressing this CQ or CC

Basic understanding of the development and hemodynamics of the lymphatic system and reagents to study the lymphatic function are available.
Lymphatic vasculature is essential for fluid hemostasis in the body, collects and returns the protein- and lipid-rich interstitial fluid to blood circulation, and also involved in immune cell trafficking and inflammation. Given these important physiological roles, function of the lymphatic system is expected to contribute to normal physiology of organs and its dysfunction to major diseases. There is very little or no information how the lymphatic system contribute to health and diseases of the cardiovascular, pulmonary and blood systems, and there are many unanswered questions. Answers to these questions may lead to new approaches for treatment of major HLB diseases. Main challenge is to get heart, lung, blood, sleep investigators interested in studying the contribution of the lymphatic system to heart, lung, blood, sleep health and diseases.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

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Goal 4: Develop Workforce and Resources

Training approaches in lymphatic biology

The lymphatic vascular network connects the parenchymal interstitium through the nodes to the veins. Lymph serves as the transport pathway between these compartments and via its flow, controls interstitial fluid, macromolecular exchange, lipid absorption, immune cell trafficking and is critical to edema prevention/resolution, lipid metabolism, inflammation and immunity. Knowledge of this vascular network lags far behind... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

NIH has acknowledged that the lack of training in the field of lymphatic biology has impaired research progress in the area. Traditional methods that the NIH uses (T32) have not adequately addressed this issue as there are currently NO such programs in existence. One of the critical problems that must be overcome to advance the field is that few individual institutions in the US have a large enough body of lymphatic biology investigators to fit the classic training grant schemes. Overcoming this hurdle will significantly help advance research in the field. Consideration of other innovative approaches that utilize web-based or other methods to deliver distance education among local or regional institutions in this field should be investigated. Establishment of these innovative approaches would broaden the pool of investigators for research training and would significantly advance the field and thus be of high impact.

Feasibility and challenges of addressing this CQ or CC

Research in the lymphatic biology field has historically lagged behind other vascular areas. However, interest in lymphatic biology and medicine has grown rapidly over the last decade. The Lymphatic Education & Research Network (formerly LRF) has had a long-standing commitment to developing research and training in lymphatic biology through its post-doctoral fellowship program, support for conferences/symposia and by providing travel funds for early-stage investigators to attend these meetings. Since very few places in the US have enough researchers trained and active in lymphatic biology, initiatives to broaden the base for research training would have to utilize novel approaches. Thus, the challenge will be to develop training programs that can address the needs of new lymphatic biologists at multiple institutions at geographically distributed sites. Approaches that use modern communication IT technology, and distance learning methods could deliver parts of the training. But innovative approaches to incorporate training beyond didactic learning need to be developed.

Name of idea submitter and other team members who worked on this idea D. Zawieja

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