What is the level of population variation of gene regulatory networks in heart, lung, and blood and sleep disease mechanisms? Can we use different animal model strains to identify key factors in networks and modifier genes?
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ARDS remains one of the most common and lethal forms of respiratory failure in critically ill patients. Improvements in understanding the pathogenesis has not led to effective treatments, and heterogeneity of the condition precludes major advances. A national registry would serve to improve understanding of epidemiology, disease characterization (for definitions) and can identify incidence, outcome, disparities, treatment... more »
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