Showing 3 ideas for tag "non-coding"

Goal 1: Promote Human Health

Role of non-coding RNAs in cardiovascular biology and disease

Noncoding RNAs field is still in its infancy. It includes microRNA and long-non-coding RNA. Recent studies show that Non-coding RNA play important roles in the regulation of tissue homeostasis and pathophysiological conditions.
miRNA-based therapeutics showed promising results in numerous animal models of heart failure, cardiac hypertrophy, fibrosis and hyperlipidaemias, and showed success in in-human clinical trial... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

Genetic studies using gain- or loss-of- function approaches suggest that lncRNAs can indeed contribute to cardiac or vascular dysfunction. Moreover, targeting of lncRNAs in a cell-selective manner might be possible to treat cardiovascular disease. This may open up the opportunity for the development of new therapeutic strategies.

Feasibility and challenges of addressing this CQ or CC

The regulation of lncRNAs has been documented in different disease models however the function is only known for a few lncRNAs. The fact that most lncRNAs are poorly conserved and are expressed as various transcript variants challenges the identification of specific biological functions and mechanisms of action. Combination of microRNA target sequesnces and long-non-coding RNA may allow for a novel cell-selective therapies.

Name of idea submitter and other team members who worked on this idea Hana Totary-Jain

Voting

5 net votes
10 up votes
5 down votes
Active

Goal 1: Promote Human Health

Emerging importance of RNA regulation

What are the roles of RNAs (e.g., microRNAs, long non-coding RNAs, etc.) in myocardial growth, adaptation, and injury healing response?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

As an example, recent studies suggest key regulatory roles of RNAs (e.g., microRNAs and long non-coding RNAs) in cardiac pathological hypertrophy and heart failure. Better understanding of such mechanisms will spur development of new therapies based on these mechanisms.

Feasibility and challenges of addressing this CQ or CC

Most of the infrastructure and methods are in place. There appears to be growing interest and excitement about the potential of this research area. However, this field needs more researchers.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

Voting

4 net votes
18 up votes
14 down votes
Active

Goal 2: Reduce Human Disease

Role of extracellular RNAs in cardiac biology and disease

Extracellular RNAs including miRNAs, piRNAs, tRNA fragments and long non-coding RNA fragments have been found in plasma and correlated with disease. For microRNAs, there is emerging evidence of a functional role for these extracellular RNAs in cardiovascular diseases. However, there needs to be a concerted effort to: 1) develop new models and tools to study the role of these entities; 2) validate findings from different... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea Saumya Das

Voting

-7 net votes
4 up votes
11 down votes
Active