Showing 10 ideas for tag "pathophysiology"

Goal 2: Reduce Human Disease

Characterizing tissue response to injury

Can we characterize in detail the nature of tissue response to injury, resulting in either aberrant repair or regeneration, to generate predictive algorithms and targetable nodes where manipulation can alter the outcome?

 

Can we characterize tissue remodeling, repair and injury? What processes are involved that lead to outcome X and dependent on various perturbegens, genetics? How do you translate that?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea NHLBI Staff

Voting

13 net votes
22 up votes
9 down votes
Active

Goal 2: Reduce Human Disease

The effects of environmental factors on heart, lung, blood, sleep disease development across the lifespan

How do growth, development, exposure, and behavior affect heart, lung, blood, sleep disease development and outcome throughout the lifespan?

 

How do you improve organ function/capacity during childhood?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Defining earliest elements of disease and strategies for prevention

Feasibility and challenges of addressing this CQ or CC

If we don’t start now, it will never get done
. Challenges:
• Determine if elements of cell aging, including stem cell aging and senescence, affect disease progression and the effectiveness of therapeutic interventions
• Can we develop iPS based or other cell based bioengineered tools to more precisely define cellular and molecular responses to particular exposures?
• How do we identify, prioritize and measure relevant environmental exposures?

Name of idea submitter and other team members who worked on this idea NHLBI Staff

Voting

12 net votes
32 up votes
20 down votes
Active

Goal 2: Reduce Human Disease

Enabling technologies that improve the precision and depth by which we evaluate people

How do we enable technologies that improve the precision and depth by which we evaluate patients to better understand pathophysiology and develop, test and optimize therapy?

 

Use of EHR to understand HLB disease?

Should NHLBI/researchers have a larger role in the development of the EHR?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Generation of more relevant models for accelerating mechanistic and therapeutic studies.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

Voting

5 net votes
16 up votes
11 down votes
Active

Goal 3: Advance Translational Research

Cohort studies and clinical trials in vascular disease

Utilization of well characterized cohort studies and clinical trials to conduct ancillary scientific studies on pathophysiology, responses to treatment, and identify new ways to predict and treat disease. Restore the Ancillary Studies mechanism. Improved biobanks and data sharing platforms are needed. Facilitate public-private partnerships.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea Society for Vascular Surgery

Voting

2 net votes
3 up votes
1 down votes
Active

Goal 3: Advance Translational Research

The need for funding priorities and emphasis on valve disease and large-animal preclinical studies

Investigators need NHLBI support for programs that transform our approach to heart valve disease to mechanism-based prevention with large-animal preclinical studies through: an NHLBI-sponsored sponsored Heart Valve Network; development of models of genetic and acquired valve disease; a study section devoted to valve disease; and RFAs and RFPs based on Task Force priorities in mitral valve disease.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Improved health through mechanism-based prevention in an increasing cause of heart failure. Support for research that can lead directly to clinical applications yet has basic aims.

Feasibility and challenges of addressing this CQ or CC

With NHLBI support, the resources and talented investigators can make this possible.

Name of idea submitter and other team members who worked on this idea Robert A. Levine, MD and member of the Leducq Mitral Network

Voting

2 net votes
4 up votes
2 down votes
Active

Goal 3: Advance Translational Research

Developing Curative Approaches to Cardiovascular Disease rather than Chronic Magement

Most Pharmacological interventions in cardiovascular diseases tend to address to be used in palliative manner and chronically. There is urgent need for treatments that are curative. This goes to identifying molecular drivers of the diseases and targeting them to correct the underlying pathophysiology rather than symptom suppression.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

True conquer of cardiovascular diseases, and reversing the chronic nature of these diseases.

Feasibility and challenges of addressing this CQ or CC

Possible but challenging requiring a highly multidisciplinary approach and collaboration.

Name of idea submitter and other team members who worked on this idea John. K. Buolamwini

Voting

1 net vote
2 up votes
1 down votes
Active

Goal 2: Reduce Human Disease

Defining the developmental abnormalities leading to birth defects

Can we define the developmental abnormalities leading to birth defects and extrapolate that knowledge to define strategies for regeneration?

 

How can we recognize initiation of disease earlier?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea NHLBI Staff

Voting

-1 net votes
8 up votes
9 down votes
Active

Goal 2: Reduce Human Disease

Assessing gene knockout humans more effectively

What insights can be gathered from patients with single gene functional mutations to improve our understanding of the pathobiology of human disease?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea NHLBI Staff

Voting

-9 net votes
5 up votes
14 down votes
Active

Goal 3: Advance Translational Research

Factors affecting ischemia and reperfusion

What is the impact of age, gender, and comorbidities on pathophysiology and treatment of total body ischemia and reperfusion, and how should therapies be modified accordingly?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea AHA Staff & Volunteers

Voting

-1 net votes
2 up votes
3 down votes
Active