Showing 3 ideas for tag "resistance"

Goal 3: Advance Translational Research

treating sleep apnea without a nose or facial mask

I am lucky to still be alive. I developed heart failure at 41. I turn 60 this month. For the last five years, doctors have tried to get me on a CPAP. I have told them that I'd rather die. I have absolutely no interest in sleeping with a darth vader mask or some strange thing strapped to my nose. Furthermore I had sinus surgery 30 years ago that only partiallly cleared my sinus passage. So forcing air up my nose is very... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

If my doctors are correct, patients like myself are at high-risk. Before we die, we will need expensive hospital or nursing home based care. If some one can develop a mask or device that will work, he or she will literally save lives and reduce the financial burden on families, communities and hospitals.

Feasibility and challenges of addressing this CQ or CC

This shouldn't be difficult research. We're talking about an air delivery system, not a cure for cancer or AIDS. The challenge is that this is not a prestige issue. There won't be a lot of research centers spending on on this.

Yet it could save lives and reduce healthcare costs. Maybe this research could be conducted as a joint project of associations for ENT doctors, cardiologists and dentists.

Name of idea submitter and other team members who worked on this idea Mary Crystal Cage

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Goal 2: Reduce Human Disease

Contribution of non-lipid factors to atherosclerotic vascular disease

Despite the generally accepted thesis linking lipids to atherosclerosis, a large number of patients fail to benefit from statins, the current lipid-lowering drugs of choice. Moreover statins are reported to cause diabetes and severe muscle weakness in some patients thus adding to the general conundrum associated with statin therapy. This prompts an important, yet unresolved question related to non-lipid factors contributing... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea Priya Raman

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Goal 2: Reduce Human Disease

What pathobiology underlies the interaction of the diabetogenic hormone amylin with vascular media ?

Amylin is synthesized and co-secreted with insulin by pancreatic beta-cells, plays a complex role in peripheral energy homeostasis, and shows also a high propensity to oligomerize when overexpressed (hyperamylinemia). Accumulation of oligomerized amylin is a pathological hallmark of the islet in diabetic patients and induces oxidative stress, inflammation and apoptosis. However, recent studies found significant deposits... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

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9 down votes
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