Showing 4 ideas for tag "rhythms"

Goal 2: Reduce Human Disease

Circadian strategies to improve therapies

What circadian-based strategies (e.g. timing of medication) can be applied to improve the efficacy of treatments for heart, lung, and blood diseases (e.g. hypertension, nocturnal asthma, thrombosis, obesity/diabetes)?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

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Goal 1: Promote Human Health

Circadian Environmental Effects

Does circadian regulation modify the effects of environmental exposures (e.g., cigarette smoke, particulates, virus/bacteria, temperature, humidity, microbiome) on airway/lung remodeling and the intensity of associated epigenetic modifications?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Feasibility and challenges of addressing this CQ or CC

An estimated >90% of histone modifiable sites on human chromatin are clock-coupled.

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Goal 2: Reduce Human Disease

Understanding of chronobiological systems

We know that all life functions are based on circadian and other rhythms; chronobiological systems are interdependent in intricate ways. Disturbances and disorders in one part of a system may affect other vital systems in unexpected but far-reaching ways.

Many aspects of circadian rhythms and sleep-wake regulation in normal, healthy humans have been charted. Much of the knowledge thus gained is assumed to be valid also... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

As research on the extrinsic Shift Work Disorder shows, disturbances of the normal person’s sleep-wake cycle have consequences. These may include excessive daytime sleepiness, increased risk of traffic and other accidents, dysregulation of metabolic and other systems, obesity, increased risk of cancer, cardiovascular diseases, mood disorders and other diseases. Normal people trying to function on an abnormal schedule may develop conditions that lead to disability or death. Intrinsic CSWD patients suffer many of the same conditions as well as others.

These patients desperately need answers: Why am I like this, Do I dare have children, Will it get worse as I age, Can anything be done in addition to light boxes, scototherapy and melatonin, What is really the best timing in use of these treatments, Will I get disability?

Research on these patients will likely lead to discoveries that could be the target for future studies, thus impacting the modern fields of sleep and circadian rhythms research.

Feasibility and challenges of addressing this CQ or CC

The intrinsic CSWDs are:

  1. Lifelong DSWPD, delayed sleep-wake phase disorder
  2. Adolescent DSWPD
  3. ASWPD, advanced sleep-wake phase disorder
  4. ISWRD, irregular sleep-wake rhythm disorder
  5. Blind Non-24, N24SWRD, non-24-hour sleep-wake rhythm disorder in the blind
  6. Sighted Non-24, N24SWRD in the non-blind.

I have listed 6 disorders; the usual number is 4. The first 2 on my list are usually combined, as are the last 2.

Some of the challenges, for different age groups and degrees of severity, are to:
--Find the causes of the disorders that are not yet explained
--Examine genetics and heritability
--Differentiate teens’ DSWPD as adolescent or persistent type
--Discover why adult DSWPD often precedes the development of Non-24 in sighted people
--Validate the use of light therapy, dark therapy and melatonin, including detailed recommendations for the timing and dosage of each of them
--Find other, more reliable, treatments
--Develop simple tests for determining persistent internal circadian desynchronization in an individual.

 

Some of the disorders have been explained, in whole or in part. There is great need for work with, at least, the following groups of patients:
-Adult DSWPS
-Pre-puberty children w/ DSWPS
-Adult sighted N24
-Pre-puberty sighted children w/ Non-24

Of these, adults with DSWPD are, of course, the most numerous. Research on that disorder may lead to results of interest for N24, these disorders being closely related.

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Goal 2: Reduce Human Disease

Circadian patterns of injury/repair pathways

What is the role of clock-dependent mechanisms in cell injury/repair pathways and tissue dysfunction in heart, lung, and blood pathophysiology? How are pathways involved in disease and repair affected by aging-dependent mechanisms?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

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