Goal 3: Advance Translational Research
Hypoxia, acute chest syndrome and sickle cell disease
What markers in sickle cell disease can predict hypoxia after acute chest syndrome or pneumonia?
Voting
The treatment of asthma in patients with SCD prevents the development of ACS and VOS.
Does the aggressive treatment of asthma prevent the developement of acute chest syndrome (ACS) and vaso-occlusive syndrome (VOS) in patients with sickle cell disease (SCD)?
Voting
Intervening on Metabolic Derangements Induced by Allogeneic Hematopoietic Stem Cell Transplantation
Can standardized screening, pharmacological/behavioral prevention, and optimized treatment of metabolic complications after allogeneic hematopoietic stem cell transplantation improve outcomes and decrease transplant-related morbidity and mortality?
Voting
Imaging indicators of metabolic syndrome and cardiopulmonary disease
Critical Challenge
Voting
Is there a Biomarker for the Pulmonary Fibrosis of HPS?
Hermansky-Pudlak Syndrome is characterized by a bleeding disorder as well as pulmonary fibrosis. Invasive procedures such as a lung biopsy are contraindicated due to bleeding and bronchoscopy is not without risk. Finding a biomarker would reduce the necessity for more invasive data collection while improving outcomes.
Voting
Goal 3: Advance Translational Research
Obesity in special needs populations: Congenital heart disease
What are effective prevention and treatment strategies for populations with special needs, such as those with congenital heart disease, Down syndrome and preterm-born, to maintain a healthy weight?
Are there successful strategies derived from "normal" populations that could be effectively applied to these populations?
Voting
Goal 3: Advance Translational Research
Detection of inflammatory monocytes as a biomarker of CVD
Voting
Goal 3: Advance Translational Research
Increasing the adoption of low tidal volume ventilation in ARDS patients
How can we use implementation science to increase the adoption of low-tidal volume ventilation in patients with acute respiratory distress syndrome (ARDS)?
Voting
Postural Orthostatic Tachycardia Syndrome: Mechanisms and Treatments
Examine the mechanisms of POTS and develop effective treatments.
Voting
Ehlers-Danlos Syndrome: Effects on Cardiac Function
How does Ehlers-Danlos Syndrome affect the functioning of the heart and circulatory system?
Voting
Sex and Race Differences in Replacement Lung Surfactant Efficacy
Voting
Goal 3: Advance Translational Research
Screening the work force for genetic arrhythmias
Is anyone in your family at risk for a potentially lethal genetic arrhythmia? 4000 young people die each year because they bear a genetic mutation that makes them susceptible to a sudden fatal arrhythmia. The symptoms are easy to identify and awareness of these symptoms would help unsuspecting families.
It is estimated that one of these syndromes (LQTS) is 3 times more common in the US than childhood leukemia.