What is the optimal management approach to severe asymptomatic calcific aortic stenosis (surgical aortic valve replacement (AVR) or deferred surgical AVR until development of symptoms (watchful waiting))?
What is the optimal use of new direct oral anticoagulants?
What is an appropriate risk score for intervention in valvular heart disease?
Global health system outcomes studies are needed to identify impediments to successful primary and secondary prevention of rheumatic heart disease.
Other approaches, such as development of a vaccine for group A streptococcus and delaying disease progression once valve damage is present, could also be explored.
What is the optimal use of antibiotics for prophylaxis of infective endocarditis?