Showing 3 ideas for tag "work"

Goal 1: Promote Human Health

ELUCIDATING BASIC MECHANISMS OF SLEEP DEFICIENCY AND CIRCADIAN DISRUPTION ON HEALTH THROUGH THE LIFESPAN

There are developing data from clinical studies that sleep deficiency and circadian disruption have multiple adverse consequences for health. The clinical data provide the base for mechanistic studies. Studies in animal models indicate that both circadian disruption and insufficient sleep later gene expression in peripheral tissues. Moreover, the effect of sleep loss in molecular changes in brain changes with age.... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

There is no doubt that insufficient sleep and circadian disruption are very common in our society. There are also compelling epidemiological data that they are associated with multiple adverse consequences, including increased cardiovascular disease, increase in metabolic abnormalities such as insulin resistance and for shift work an increased incidence of specific concern. Animal studies based on microarrays are showing that inadequate sleep and circadian rhythm alter gene expression not only in brain but also in peripheral tissues. These studies are hypothesis-generating and there are many opportunities for hypothesis-driven research in this area to assess mechanisms. Identifying mechanisms will allow investigators to begin to assess mechanisms of individual differences and to identify new pathways for intervention.

Feasibility and challenges of addressing this CQ or CC

Sleep and circadian research is in a very strong position. Sleep and clock function has now been identified in all the major model systems—C. elegans, Aphysia, Drosophila, zebra-fish, mice, etc. Thus, there is a strong platform to assess conserved pathways for effect of sleep loss and circadian disruption. Moreover, microarray studies have identified likely pathways thereby setting up hypothesis-driven research. There are major opportunities in this area.

Name of idea submitter and other team members who worked on this idea Sleep Research Society

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Goal 4: Develop Workforce and Resources

Strategic Visioning Initiative is just a beginning: it needs a mechanism for implementation

NHLBI Strategic Visioning Initiative is a good idea. You have received a score of useful suggestions from Academia and business. But like and good idea, it needs someone to follow through. Otherwise your new beautiful plans for cardiovascular research may die without a significant impact.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

When the plans are completed, the work just begins. Above all, you have to find people to carry out the plans passionately but quietly, i.e., without exuberant desire to report before the results are obtained.

Feasibility and challenges of addressing this CQ or CC

The study by Merilee Grindle of the Harvard Kennedy School "Good Governance: The Inflation of an Idea" may be very useful.

Name of idea submitter and other team members who worked on this idea Nikolai M. Soldatov, Ph.D.

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Goal 2: Reduce Human Disease

Conduct a clinical trial whether maximizing melatonin using orange eyeglasses in the evning reduces breast cancer.

Epidemiological studies have shown totally blind women have about half the incidence of breast cancer as blind women who retain light control of melatonin suppression or of women with normal vision. Studies show shift worker that reduces melatonin and disrupts the circadian rhythm increases the risk of breast cancer. Studies show human breast cancer grafts grown on rats but supplied with human blood grow rapidly if the... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

About 250,000 new cases of breast cancer are diagnosed each year in just the U.S. The evidence suggests this number could be cut in half by simply changing to low-blue light bulbs or by wearing blue blocking glasses for a few hours before bedtime. A similar situation exists for prostate cancer. Without clinical trials the medical community will not believe it is true, despite all the evidence.Since there are no expensive drugs involved, no drug company will fund this type of trial so the federal government or foundations are the only likely funders. Reducing breast cancer incidence to half is worth billions of dollars to say nothing about the reduction in human suffering.

Feasibility and challenges of addressing this CQ or CC

By using women at high risk for cancer the time to carry out a trial of modest size will be reduced. Since there is essentially no risk and improved sleep is a side effect, compliance should be high.

Name of idea submitter and other team members who worked on this idea Richardd L. Hansler PhD Edward Carome PhD Vilnis Kubulins MS

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