Seeking the secret behind “resilience” to a variety of HLBS diseases
What is the secret behind the “resilience” some people have to heart, lung, blood, and sleep (HLBS) diseases?
Voting
Role of epigenetic mechanisms in cardiovascular disease
If they are the cause, what are the mechanisms that lead to changes and how do they impact disease pathogenesis?
If the consequence, do they play any role in disease pathogenesis?
What methods can be used to test if epigenetic changes play a causal role in disease pathogenesis? Thus far studies... more »
Voting
COPD and co-morbidities
The critical question is whether certain diseases occur together by chance or are they occurring together because they share pathobiological commonalities and mechanisms? This leads to a series of practical consequences and questions
1. Which diseases are occurring concurrent with COPD more than chance alone would... more »
Voting
RCT of stepped-care depression treatment on CV events & death
Does treating depression improve survival and reduce major adverse cardiac events in acute coronary syndrome patients?
Voting
Additional research needed to identify various contributors of obesity
What are the specific contributors of obesity that lead to chronic positive energy balance and surplus energy storage?
Voting
Consequences of ABO or Rh Type Specific versus Non-Type Specific Platelet Transfusions
Voting
Treatment Options for Diabetics and Impact on Cardiovascular Health
Voting
Transforming Clinical Practice through Patient-Centered Medical Nutrition and Lifestyle Education
Voting
Sleep Disorders and Brain Maturation
What is the effect of sleep disorders on child development? Specifically, how sleep apnea with intermittent hypoxia and or sleep deprivation alters the normal trajectory of maturation of brain regions controlling cognition, behavior and the cardiovascular system?
Voting
What is the role of diet and nutrition in treatment, management and prevention of Heart Failure?
Voting
Defining critical elements for irreversible myocardial injury
What are the critical mechanisms that account for progression from reversible to irreversible ischemia and reperfusion injury?
Voting
Translational and basic research on high triglycerides as an additional risk for cardiovascular disease.
Compelling Question (CQ)
Voting
Can one integrate cardiac imaging studies with genetic,clinical, "omics", and historical data to predict disease and personalize
Voting
Why does loss of endoglin in adult blood cells lead to cardiac hypertrophy in HHT patients
Liver arteriovenous venous malformations creates a high flow shunt that over time creates high output cardiac failure with no effective treatments.