Asthma-COPD overlap syndrome is common and associated with increased morbidity and greater healthcare costs. However, ACOS patients are usually excluded from studies of either disease. There is a compelling need for research in order to define objective diagnostic criteria for ACOS.
Does the aggressive treatment of asthma prevent the developement of acute chest syndrome (ACS) and vaso-occlusive syndrome (VOS) in patients with sickle cell disease (SCD)?
How can we improve communication between schools and clinicians in order to develop support systems for children with severe asthma with health disparities?
How can we eliminate inefficiency in medical communication to better serve children with severe asthma?
What are the most effective methods to reduce asthma disparities in low income children?
What is the effectiveness and safety of treatment of the co-morbid condition of asthma with medications known to improve asthma outcomes in individuals without SCD?
For example: 3 cycles of Duoneb and Albuterol, monitoring pulsoximetry, with oral / IM Dexamethasone dosage. Also initiation of controller medication at... more »
Molecular mechanism controlling airway hypersensitivity and remodeling
Prospective studies on acetaminophen and asthma - randomized/controlled/adequately powered - use in pregnancy and asthma development in utero, use in early childhood
Adequately powered randomized vitD trials - as primary prevention, and after asthma diagnosis
Bronchial thermoplasty in oral steroid-dependent (high dose certainly >10 mg/day) asthmatics
ICS/LABA/tiotropium fixed triple-combination inhaler therapy
Are there biomarkers or phenotypic characteristics that will allow us to identify the patients with asthma who will experience a more rapid decline in lung function?