The effects of environmental factors on heart, lung, blood, sleep disease development across the lifespan
How do growth, development, exposure, and behavior affect heart, lung, blood, sleep disease development and outcome throughout the lifespan?
How do you improve organ function/capacity during childhood?
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Systems approaches to understand the pathogenesis of cardiovascular diseases, combined with in vivo validation
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How to maximize the opportunities and promise of emerging omics research? Develop scientific commons
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Vascular biology and the pathophysiology of sepsis
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National network to study the pathobiology of sepsis
Sepsis is the leading cause of death in hospitalized patients, the 3rd leading cause of death in all people in the US, the most common condition leading to widespread vascular collapse, among the most common causes of respiratory failure, and a frequent cause of acute cardiac dysfunction.
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Using "omics" for therapeutic targets
How do we identify potential targets for therapy in the age of systems biology/genomics?
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Defining the developmental abnormalities leading to birth defects
Can we define the developmental abnormalities leading to birth defects and extrapolate that knowledge to define strategies for regeneration?
How can we recognize initiation of disease earlier?
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Bringing Personalized Biochemistry and Biophysics to Bear on Problems of Personalized Heart, Lung and Blood Medicine
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Novel methods to diagnose and treat microvascular ischemia
Microvascular ischemia is common, particularly in the setting of critical illness. We need better ways to evaluate, diagnose and treat these conditions, whether they relate to microvascular myocardial ischemia, as a primary diagnosis of complication of other acute illness, or non-myocardial ischemia during the course of surgery, injury, infection or acute illness.