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Goal 2: Reduce Human Disease

Mechanical interaction of the cerebral vascular system with the brain parenchyma during mild traumatic brain injury

Dangerous mechanical interaction of the cerebral vascular system with the brain parenchyma during mild traumatic brain injury from either a blast wave or from impact may result from a combination of shear and compression deformation waves that causes non-diffusive extracellular fluid motion. Measure the mechanical response, to a combination of shear and compressive deformation, of animal model specimens containing the... more »

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(@ceci00) kudos icon +

Goal 2: Reduce Human Disease

Understanding Glymphatic Pathways and Waste Clearance abnormalities in brain disease

Cerbrospinal fluid flow and waste clearance through glyphatic pathways are likely to be important in numerous brain diseases including such devastating diseases such as alzheimer's , parkinson's, stroke and migraine. However, relatively little is known about the brain's waste clearance mechanisms, and how failure in these systems may underlie brain disease. Build up of proteins and calcification have been shown to... more »

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