Stem Cell Biology
There is a need to develop an artificial and functional hematopoietic stem cell (HSC) niche that allows for the expansion of repopulating HSCs.
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Stem Cell Immunology
How does the immune... more »
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Engineered ECM for heart repair
Utilizing advances in nano, bio, tissue and related engineering technologies to construct cardiac ECM for heart repair.
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Harnessing Lung Regenerative Capacity to Improve and Increase Donor Lungs for Transplantation.
Using knowledge of matrix biology and lung development, what are useable methods to modify cadaveric donor lungs to provide a durable, effective organ replacement therapy?
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Influence of the Gut Microbiome on Pulmonary Immunity in HIV-Infected Individuals
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Mitigating risks due to the RBC storage lesion and vulnerable patients
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Biology of the intact alveolar wall – the new frontier in lung research
HOW DO WE STUDY THE BIOLOGY OF THE INTACT ALVEOLAR WALL IN THE CONTEXT OF LUNG DISEASE AND REPAIR?
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Human Lung Progenitor Cells, Lung Epithelial Differentiated iPSCs, and Therapeutics
What are the biological properties and key surface markers of human lung progenitor cells and lung epithelial differentiated iPSCs? How can these cell populations be targeted for therapeutic purposes, including regenerative therapy?
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Lung cell stimuli responses
What alterations in respiratory epithelia in response to environmental / external insults are irreversible and lead to disease onset or progression?
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Genetic engineering in lung progenitor cells
Can genome engineering be used to correct or alter lung stem/progenitor cells to ameliorate lung disease and promote regeneration?
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Lung progenitors and disease
What is the role of lung stem/progenitor cells in disease?
Which diseases involve stem cell defects?