Showing 8 ideas for tag "drug"
(@nhlbiforumadministrator1) kudos icon +

Goal 2: Reduce Human Disease

A Program of Research in the Prevention of Chronic Heart Failure

There is a need to address chronic heart failure (HF) through improved identification of patients at risk for HF and of patients with pathological ventricular remodeling who have minimal evidence of clinical HF, and more focused and individualized pharmacologic and lifestyle treatments and monitoring of patients with HF risk. Approaches would include big data collection, omics, statistical modeling, and focused clinical... more »

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17 net votes
28 up votes
11 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 2: Reduce Human Disease

A Program of Research in the Prevention of Chronic Heart Failure

There is a need to improve identification and surveillance of persons at risk for heart failure and pathological ventricular remodeling prior to development of clinically overt heart failure.

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14 net votes
28 up votes
14 down votes
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(@wheeze) kudos icon +

Goal 2: Reduce Human Disease

Genetic and Molecular Tools for Drug Allergy - Hypersensitivity

As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:

Given that more patients are treated with newer and better targeted medications including chemotherapy, monoclonal antibodies, small molecules and others that have increased the number of hypersensitivity reactions, which... more »

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-4 net votes
10 up votes
14 down votes
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(@wheeze) kudos icon +

Goal 2: Reduce Human Disease

Drug Desensitization Protocols

As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:

Given that increasing number of patients allergic to their best medications are treated with desensitization, which allows improved quality of life and prolongs their lives, ¬†what ¬†personalized, effective and safe protocols... more »

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-9 net votes
4 up votes
13 down votes
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(@wjones7) kudos icon +

Goal 2: Reduce Human Disease

Open up NCATS

The NCATS program for drug repurposing is currently only open to drugs submitted by industry (read, big Pharma). We have had the experience of working to repurpose a generic drug not on their list, and despite great Preliminary data, we could not. This program is a great idea, but needs to be opened to any company and any drug for which solid data backing efficacy and market can be applied. Why do we only want to enhance... more »

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-5 net votes
5 up votes
10 down votes
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(@greg.martin) kudos icon +

Goal 2: Reduce Human Disease

Consequences of drug interactions leading to QTc prolongation

Better understand the consequences of drug interactions leading to QTc prolongation. About 1/3 of cardiac ICU patients develop QT prolongation and about 45% receive drugs that are possibly contributing to this problem. The full spectrum of contributors and causes, as well as the patient-centered and health-system-centered clinical outcomes, are not known.

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-1 net votes
1 up votes
2 down votes
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