What biomarkers of acute environmental exposure are predictive of disease onset or progression?
What alterations in respiratory epithelia in response to environmental / external insults are irreversible and lead to disease onset or progression?
In spite of many years of research, we still cannot predict the short term risk of a heart attack or sudden CHD death. Most CHD deaths occur outside of the hospital. In spite of improvement of out-of-hospital emergency care, most “sudden death events” are still not successfully resuscitated.