Showing 3 ideas for tag "insulin"

Goal 2: Reduce Human Disease

Contribution of non-lipid factors to atherosclerotic vascular disease

Despite the generally accepted thesis linking lipids to atherosclerosis, a large number of patients fail to benefit from statins, the current lipid-lowering drugs of choice. Moreover statins are reported to cause diabetes and severe muscle weakness in some patients thus adding to the general conundrum associated with statin therapy. This prompts an important, yet unresolved question related to non-lipid factors contributing... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea Priya Raman

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Goal 2: Reduce Human Disease

Treatment Options for Diabetics and Impact on Cardiovascular Health

As a clinician, over the years I have noted major differences in adverse cardiovascular outcomes in diabetics who are treated with insulin +/- oral agents compared to those only treated with oral agents. Cardiovascular events occur much less often and at a much later timeframe in diabetics ("Type 2/adult onset") treated with insulin as the primary method. Even with newer agents, there may be slight improvement, but... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

Delaying the onset of injury to vasculature in Type 2 diabetics would have a major impact on quality of life for the diabetic and costs to the healthcare system. Dialysis and related costs are around $200,000/yr and interfere with life and ability to work, leg ulcers are often chronic and in many cases result in amputation.

Feasibility and challenges of addressing this CQ or CC

This study could be performed in the clinical setting or could be completed with chart review to determine diabetics on insulin on insulin and review outcomes. If access to charts for patients continuously treated for five years or longer were available, this study could be done in a shorter timeframe and at less cost. A long term and costly alternative would be to begin a clinical trial. Medical claims data may be an alternative, but it would be important to identify onset of diabetes and treatment for a minimum of five years.

Name of idea submitter and other team members who worked on this idea Patricia Gladowski

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Goal 2: Reduce Human Disease

What pathobiology underlies the interaction of the diabetogenic hormone amylin with vascular media ?

Amylin is synthesized and co-secreted with insulin by pancreatic beta-cells, plays a complex role in peripheral energy homeostasis, and shows also a high propensity to oligomerize when overexpressed (hyperamylinemia). Accumulation of oligomerized amylin is a pathological hallmark of the islet in diabetic patients and induces oxidative stress, inflammation and apoptosis. However, recent studies found significant deposits... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

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