Cardiometabolic Disease Risks Associated with Sleep Deficiency
How does insufficient sleep duration, irregular timed sleep schedules, and poor sleep quality contribute to the pathophysiology of lung, heart and blood diseases?
How does insufficient sleep duration, irregular timed sleep schedules, and poor sleep quality contribute to the pathophysiology of lung, heart and blood diseases?
How can the safety, dosing and benefits of existing therapies for sickle cell disease such as hydroxyurea, be optimized in order to increase its efficacy and improve patient adherence?
What cellular and/or intracellular signaling events are activated in response to acute or chronic physical activity that lead to or explain improvements in health outcomes, prevention, or treatment of lung diseases?
Which metabolic signatures induced by exercise/physical activity would be predictive/ associated with poor lung disease prognosis?
What molecular and cellular pathways explain the sex-specific differences in the prevalence, severity, and progression of lung diseases?
What is the relationship between exacerbations and progression of chronic lung diseases?
Critical Challenge
Can a multipronged approach to reversing/repairing scar tissue in pulmonary fibrosis be deployed as soon as possible?
Critical Challenge