Showing 3 ideas for tag "mechanism"

Goal 2: Reduce Human Disease

What do the newer treatments in R&D tell us about the management of SCD?

What is the molecular mechanism by which new drug therapies propose to reduce the severity and duration of hospitalization and opioid pain medicines? And how does that impact the course of disease progression?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea Sickle Cell Warriors, Inc. community members

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Goal 2: Reduce Human Disease

Mechanisms for sex-specific differences in lung diseases

What molecular and cellular pathways explain the sex-specific differences in the prevalence, severity, and progression of lung diseases?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Understanding the molecular and cellular bases of differences in prevalence and outcomes of lung diseases will offer insight into disease mechanisms and help to address disease disparities. Some potential bases for disparities, such as differences in hormone levels between men and women, could potentially be therapeutically modulated to mitigate the effects of disease.

Feasibility and challenges of addressing this CQ or CC

The increased understanding of lung cell biology, along with a renewed focus on sex and gender differences, make this the perfect time to start addressing these questions.
Multiple diseases affecting the lung, such as LAM (lymphangioleiomyomatosis), sarcoidosis, asthma, and COPD, have distinct prevalence or associated mortality in a sex-dependent manner. The reasons for these differences are still unknown.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

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Goal 2: Reduce Human Disease

The Mechanisms Underlying the Connection Between Depression and CVD in women

There are compelling data regarding the sex-dependent intersection of depression and cardiovascular disease (both IHD and stroke). There are early data suggesting the underlying mechanisms. CVD is the number one cause of death in women and depression is the number one cause of disability with women 70% more likely to experience depression over their lives. The underlying sex-dependent mechanism is important to elucidate.... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Feasibility and challenges of addressing this CQ or CC

There has been research in this domain and furthing this line of investigation is key to the health of women (and men) world-wide.

Name of idea submitter and other team members who worked on this idea Depression and CVD in Women

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