Showing 4 ideas for tag "pregnancy"

Goal 2: Reduce Human Disease

Impact of intrauterine environment on obesity

How does maternal obesity before or during pregnancy affect the intrauterine environment and increase the risk of overweight/obesity in the offspring?

How does maternal dietary intake during pregnancy impact weight in the offspring?

What types of interventions are most effective for preventing excessive gestational weight gain among high risk groups?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Developing effective interventions during pregnancy can help reduce the risk of obesity in the offspring and mother.

Feasibility and challenges of addressing this CQ or CC

Addressing how the intrauterine environment impacts obesity is feasible because there is already existing preliminary data that shows pregnancy can have an impact on obesity in offspring. More work needs to be done to better understand the mechanism and how best to intervene.
There is emerging evidence that the intrauterine environment can have an impact on obesity.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

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33 net votes
66 up votes
33 down votes
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Goal 2: Reduce Human Disease

Decreasing risk for cardiometabolic disorders in pregnancy with a focus on preeclampsia

The prevalence of cardiometabolic disorders of pregnancy are increasing rapidly in women in the United States, particularly in black women. These disorders have a significant impact on the development of CVD in women as they age and on their offspring. The science to answer these questions are both mechanistic(understanding underlying mecanism of disease, esp preeclampsia) and behavioral. New methods of gathering... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

By addressing cardiometabolic disease in pregnancy, we have the ability to improve long-term maternal and child health. The global implications for focusing on this problem are also profound. The potential for research that spans basic, translational, outcomes and lifestyle interventions is potentially great. There is opportunity for NHLBI to partner with NICHD, and Fogarty to undertake a broad and wide initiative that has the ability to save lives in the US and globally.

Name of idea submitter and other team members who worked on this idea Paula Johnson

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1 net vote
3 up votes
2 down votes
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Goal 2: Reduce Human Disease

Maternal sleep apnea treatment effects

Does assessment and treatment of sleep apnea in pregnancy reduce the risk of maternal heart, lung and blood disease and complications associated with delivery and risk factors in offspring (e.g., obesity)?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea NHLBI Staff

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-4 net votes
19 up votes
23 down votes
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Goal 2: Reduce Human Disease

Maternal mortality due to Hemostatic Disorders

Can we decrease maternal mortality and morbidity due to hemorrhage or thrombosis?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

Hemorrhage and thrombosis remain major causes of maternal mortality in the US. New approaches are needed to decrease these tragic deaths.

Feasibility and challenges of addressing this CQ or CC

Clinical/basic study of risk factors/biomarkers to better define women at risk and clinical trials are needed to compare treatments.

Voting

-3 net votes
12 up votes
15 down votes
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