Predictors of Sickle Cell Disease Severity
Can better predictors of disease severity such as specific biomarkers and/or genetic polymorphisms be identified so as to help understand the course and progression of sickle cell disease in various patients?
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Optimization of Existing Therapies for Sickle Cell Disease
How can the safety, dosing and benefits of existing therapies for sickle cell disease such as hydroxyurea, be optimized in order to increase its efficacy and improve patient adherence?
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Sickle Cell anemia and Aplastic anemia survivors: Late effects and quality of life issues in Stem Cell Transplant Survivors
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Apheresis Medicine in the Management of Sickle Cell Disease
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Enhanced Pain Research in Sickle Cell Disease
There is a need for more enhanced pain research in order to help improve sickle cell disease patient outcomes and quality of life.
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Innovations in Red Cell Transfusion in Sickle Cell Disease
a. Adopting molecular genotyping as the standard in blood transfusion therapy.
b. Advancing new generation, anti-oxidant hemoglobin-based oxygen carriers (HBOCs) for use in emergencies such as trauma, stroke, acute hemolysis, and in transfusion in SCD and related disorders. In SCD, HBOCs have the capacity to not only serve as substitutes... more »
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How can we more safely deliver stem cells to Sickle Cell patients
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Alternative treatments in sickle cell disease
There is a growing desire for the development of alternative treatments and natural therapies for the treatment of sickle cell disease.
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Neurocognitive development and delays in sickle cell disease
Are neurocognitive developmental delays significantly present in children and adolescents living with sickle cell disease? What effect do these delays have on the overall morbidity associated with sickle cell disease?
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Hypoxia, acute chest syndrome and sickle cell disease
What markers in sickle cell disease can predict hypoxia after acute chest syndrome or pneumonia?
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The treatment of asthma in patients with SCD prevents the development of ACS and VOS.
Does the aggressive treatment of asthma prevent the developement of acute chest syndrome (ACS) and vaso-occlusive syndrome (VOS) in patients with sickle cell disease (SCD)?
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Assess the true impact of sickle cell trait on cardiovascular health across then age spectrum
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Single nucleotide polymorphisms, microarray and sickle cell disease
Do SNPs account for any of the variability seen in the phenotypic expression of sickle cell disease? Can microarray analysis be used to map these SNPs, promoting refined care plans for those living with sickle cell disease?