Showing 2 ideas for tag "aneurysm"

Goal 3: Advance Translational Research

Molecular determinants of vascular wall development and aneurysm formation that can be used as markers for early diagnosis

To increase the potential of translating basic research discoveries into the clinic, there is a need to discover molecular biomarkers that confer risk for aneurysms and vascular dissections. The creation of a nation-wide biorepository of well-defined tissue and plasma samples along with research utilizing these tissue samples employing state-of-the art proteomics, genomics and development of appropriate mouse models will... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

The challenge is the coordination of all components of the Project (i.e. development of a national biorepository along with coordination of proteomics and genomics analysis as well as proof of concept in animal models).

Feasibility and challenges of addressing this CQ or CC

This process is not feasible via the R01 funding mechanisms. The feasibility of addressing this critical challenge is excellent provided adequate resources are provided.

Name of idea submitter and other team members who worked on this idea Dudley Strickland and Selen Catania Muratoglu

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Goal 3: Advance Translational Research

How can we determine a patient’s risk of a life-threatening aortic dissection?

Even though science and technology has advanced, many of the advancements have not met the critical challenge of making significant changes in patient therapies for improved outcomes and thus have not been able to break through the translational barrier. In today’s world, risk of aortic dissection is still based purely on a crude size measurement. It is true that evidence indicates that aortic root aneurysm above 4.5... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

We need tools to assess vascular function and morphology to determine the weakness and/or strength of the aorta. We need biomarkers and predicators of outcomes for aneurysms and acute aortic dissection. We also need to understand the actual physical limitation of the aorta and where there may actual be physical barriers which cannot be overcome by drug therapies.

Utilizing singe gene disorders like Marfan syndrome can help to develop the tools needed to access not only risk but can provide candidate pathways that can contribute to more complex, common and polygenetic disorders and moving research to the preclinical and clinical stage to prioritize therapeutic targets in many related and common diseases..

Name of idea submitter and other team members who worked on this idea JGrima

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