(@nhlbiforumadministrator) kudos icon +

Goal 2: Reduce Human Disease

Therapy for lung infections

1. Monotherapy with a quinolone vs combination therapy with a 3rd generation cephalosporin. The issue of the best antibiotic treatment for severe CAP has been a major area of contention now for a decade and it is the most common cause of infectious death in the United States.
2. Combination therapy vs monotherapy for pneumonia due to Pseudomonas. This is another major area of contention – for nearly 2 decades, and generates... more »

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1 net vote
1 up votes
0 down votes
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(@nhlbiforumadministrator1) kudos icon +

Goal 2: Reduce Human Disease

New ideas from drug-induced cardiotoxicity

What are the fundamental mechanisms of drug, chemical, or biologics-induced cardiotoxicity (e.g., which proteins or signaling targets are most vulnerable)? Would such knowledge lead to understanding of the most critical signaling systems and contribute to development of new therapeutic (cardioprotective) strategies?

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19 net votes
45 up votes
26 down votes
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(@csaper) kudos icon +

Goal 2: Reduce Human Disease

What are the biological consequences of sleep loss or disruption and how can they best be avoided?

Arousals in obstructive sleep apena (OSA) are life saving, but the associated disruption of sleep is now thought to cause cognitive impairment, increased risk of high blood pressure and atherosclerosis, as well as glucose intolerance and metabolic syndrome. The mechanisms for these downstream effects, however, are not well understood. Can these specific pathophysiological mechanisms be identified, and can ways for mitigating... more »

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96 net votes
125 up votes
29 down votes
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(@societyforvascularsurgery) kudos icon +

Goal 2: Reduce Human Disease

Data from regulatory studies a barrier to evidence-based medicine

Alignment of regulatory, healthcare, and research arms of the government is poor. There is a need to improve the design, quality and usefulness of data from regulatory studies to address major clinical questions and also to facilitate scientific inquiry. This is a barrier to evidence based medicine and improved treatments.

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2 net votes
3 up votes
1 down votes
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(@stanley.szefler) kudos icon +

Goal 2: Reduce Human Disease

Linking Clinics and schools to improve asthma control and reduce health disparities

How can we improve communication between schools and clinicians in order to develop support systems for children with severe asthma with health disparities?

 

How can we eliminate inefficiency in medical communication to better serve children with severe asthma?

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6 net votes
12 up votes
6 down votes
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(@ryanr0) kudos icon +

Goal 1: Promote Human Health

Developmental Origins of Adult Lung, Heart and Blood Disease

It all starts in childhood. Yet it is difficult to find funding to really study these questions because the follow up timeline is long and thus very expensive but critically important. We don't even know what the "right" way to feed infants is in the first year of life to both limit cardiometabolic syndrome but also preserve neurodevelopmental outcome. We also have just started to see the tii of the iceberg in understanding... more »

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22 net votes
41 up votes
19 down votes
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Goal 2: Reduce Human Disease

Gene Therapies to Revitalize/Regenerate Cardiac Function

There is a need to examine the use of recombinant DNA to the heart for correction of genetic abnormalities or restoration of normal signaling pathways to prevent heart failure. However, gene therapy is a complex process and more studies are needed in which tissue targeting, route of delivery, regulation of target gene expression, therapeutic dose, and identification of robust biomarkers are further investigated.

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-18 net votes
8 up votes
26 down votes
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(@lungmatbio1) kudos icon +

Goal 3: Advance Translational Research

Next Stage of COPD Discovery

1) Refinement of COPD subphenotypes for therapeutics, diagnostics and mechanistic interrogation. The NIH should encourage a strong focus on a) rigorous, mechanistically-reinforced definitions (chronic bronchitis, emphysema (with and without obstruction), frequent exacerbators, combined pulmonary fibrosis and emphysema) and 2) the development and optimization of animal model systems that replicate the different subphenotypes.... more »

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16 net votes
26 up votes
10 down votes
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(@xuejunparsons) kudos icon +

Goal 3: Advance Translational Research

Deriving Cardiac Elements from Pluripotent Human embryonic Stem Cells for Heart Reconstitution

to date, the existing markets lack a clinically-suitable human cardiomyocyte source with adequate myocardium regenerative potential, which has been the major setback in developing safe and effective cell-based therapies for regenerating the damaged human heart in cardiovascular disease.

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-33 net votes
10 up votes
43 down votes
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(@mtseng) kudos icon +

Goal 1: Promote Human Health

Improve understanding of cardiometabolic health in Asian Americans

We are only now beginning to recognize that certain Asian American subpopulations are at high risk for cardiometabolic (CM) disorders thanks to recent ethnicity-specific studies (e.g., MASALA study). For the most part, however, our understanding of CM risk in Asian Americans is based on aggregated data. Further, a perception remains that other, understudied groups (e.g., Chinese Americans) are at low risk because of their... more »

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1 net vote
5 up votes
4 down votes
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(@akirasekikawa) kudos icon +

Goal 2: Reduce Human Disease

Pulse wave velocity

Cardiovascular field has been seeking novel risk factors which are 1) independently associated with clinical outcomes beyond and over traditional risk factors, and 2) powerful in identifying high risk individuals who are classified as intermediate risk by traditional model, e.g., Framingham Risk Score. Currently coronary artery calcification (CAC) is considered to pass the test. Seeking for new biomarkers that meet these... more »

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1 net vote
3 up votes
2 down votes
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(@judith.l.bettencourt) kudos icon +

Goal 3: Advance Translational Research

Translational research supporting stem cell therapy for cardiovascular disease

Translational research supporting stem cell therapy for cardiovascular disease, including: core laboratories for preclinical IND-enabling studies (e.g., PACT), and clinical trials networks for evaluating promising new treatments (e.g., CCTRN).

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115 net votes
149 up votes
34 down votes
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Goal 2: Reduce Human Disease

A Systems Approach to Obesity

There is a need to use an integrated systems approach to obesity prevention and treatment. Obesity is a complex phenotype influenced by factors from the molecular to the socio-economic level. To address the causes and prevention of obesity, we need to integrate information at the molecular level with behavioral, social and environmental data. This will require investigators in molecular biology, genetics, epidemiology,... more »

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97 net votes
138 up votes
41 down votes
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