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Goal 2: Reduce Human Disease

Research in new methods for large simple trials

We need new ideas in how to make clinical trials more efficient and cost effective. (Randomized) comparison of different methods for accrual might be of interest; blinded versus unblinded trials; behavioral controls versus placebo controls or usual care controls might be explored.

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7 net votes
16 up votes
9 down votes
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(@nareg.roubinian) kudos icon +

Goal 2: Reduce Human Disease

The potency and safety of transfusable red blood cells

Can we identify approaches to improve potency and/or safety of transfusable RBCs?

42 day pre-transfusion storage of RBCs maximizes utilization, while minimizing waste. However, RBCs undergo changes during collection, manipulation and storage that may reduce their potency or safety. Progress in understanding markers that predict transfusion success at the time of collection and with storage remains slow. New technologies... more »

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14 net votes
31 up votes
17 down votes
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Goal 2: Reduce Human Disease

Reducing CV events in breast cancer survivors -knowledge gaps

Identifying breast cancer survivors at high risk for CV morbidity and mortality to allow targeting of management strategies to reduce CV events and thereby improve overall cancer-related survival.

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-1 net votes
5 up votes
6 down votes
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Goal 2: Reduce Human Disease

Psychological & Behavioral Phenotyping to Improve Weight Control

What information is needed to improve our understanding of individual characteristics and processes that explain or predict dietary intake patterns, initiation or sustained engagement in physical activity, and sedentary behavior so that we can improve treatment matching and identify novel targets for more efficacious individual- and population-level approaches for weight management?

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29 net votes
50 up votes
21 down votes
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(@meier016) kudos icon +

Goal 2: Reduce Human Disease

Preventing hospitalization of asthma patients through agressive acute asthma management

Develop simplified agressive acute asthma treatment protocol and promote the implementation for primary care, ED, Urgent care, Internists, Pediatricians, Allergists, Pulmonologists, and Families. Goal is to prevent hospitalization of children and adults with asthma.
For example: 3 cycles of Duoneb and Albuterol, monitoring pulsoximetry, with oral / IM Dexamethasone dosage. Also initiation of controller medication at... more »

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0 net votes
7 up votes
7 down votes
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(@mariannes.clancy) kudos icon +

Goal 2: Reduce Human Disease

Will Novel Therapies Create Bleeding Remission HHT and Angiogenic Disorders

Chronic bleeding due to epistaxis and gastrointestinal bleeding telangiectasia in HHT leads to transfusion dependence, iron infusion dependence,

decreased quality of life and premature death.

 

Novel therapies such as pomolidamide, Avastin and pazopanib may be new promising therapies to lead to remission in bleeding and reduce the burden of disease

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1 net vote
2 up votes
1 down votes
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Goal 2: Reduce Human Disease

A Program of Research in the Prevention of Chronic Heart Failure

There is a need to improve identification and surveillance of persons at risk for heart failure and pathological ventricular remodeling prior to development of clinically overt heart failure.

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14 net votes
28 up votes
14 down votes
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