(@teresabarnes) kudos icon +

Goal 3: Advance Translational Research

The Future of Fibrosis Research

A critical challenge in the area of fibrosis research (including heart, lung and other organs) is the absence of a central system to act as air traffic control for progress, innovations and gaps in the science. Like the area of cancer research was 30 years ago, the fibrosis research area is fragmented and disconnected. The answer in the cancer effort to creating a centralized, focused system was with the National Cancer... more »

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3 net votes
6 up votes
3 down votes
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(@jimandmarynelson) kudos icon +

Goal 3: Advance Translational Research

Brief vs. teach-to-goal interventions in teaching patients with COPD to use inhalers

What is the comparative effectiveness of brief interventions to teach patients respiratory inhaler use (e.g., verbal and written instructions) vs. teach-to-goal interventions (brief interventions plus demonstration of correct technique, patient teach-back, feedback, and repeat instruction if needed) on respiratory inhaler technique and patient-reported outcomes (symptom frequency, activities of daily living, quality of... more »

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13 net votes
16 up votes
3 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 3: Advance Translational Research

Develop an Effective and Functional Biological Pacemaker

There is a need to develop a biological pacemaker for pediatric patients that would react to neurohumoral factors that normally modulate heart function, as well as adapt to the growing heart.

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8 net votes
23 up votes
15 down votes
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(@robert.paine) kudos icon +

Goal 3: Advance Translational Research

Understanding heterogeneity in ARDS

ARDS is a syndrome, yet we treat it as though it was a single clinical disease. There has been success in improving the process of care for patients with ARDS, but no real progress on address the underlying process. For successful therapies to influence the disease process, we need to be able to distinguish the mechanisms active in individual patients and so that we can design and test interventions targeting the specific... more »

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0 net votes
3 up votes
3 down votes
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(@collerb) kudos icon +

Goal 3: Advance Translational Research

Validating surrogate/intermediate clinical outcome endpoints for ST segment elevated myocardial infarction (STEMI)

The introduction of troponin assays has changed the criteria for myocardial infarction (MI), with much smaller myocardial damage now classified as an MI. Since to date, the FDA has not approved new agents based on their decreasing size of an MI, regulatory approval has required endpoints like death or heart failure that require large numbers of patients and long periods of time. Thus, it is difficult to attract industry... more »

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1 net vote
2 up votes
1 down votes
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(@danny.bluestein) kudos icon +

Goal 3: Advance Translational Research

Greating grant mechanism for fostering collaboration with industrial partners

There is a disconnect between the cardiovascular devices industry and the basic research that is conducted in the field by biomedical engineering researchers. Technological solutions that the industry is converging to are not well informed by the advances in basic translational research. A distinct funding mechanism should be created for fostering such collaborations. To motivate for profit cardiovascular device manufacturers... more »

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1 net vote
9 up votes
8 down votes
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(@nhlbiforumadministrator1) kudos icon +

Goal 3: Advance Translational Research

Pathways for Developing Pediatric Medical Devices

There is a need to develop innovative means to attract appropriate medical device industries to develop devices for the treatment and/or diagnosis of cardiovascular, pulmonary, or blood diseases in young children.

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13 net votes
23 up votes
10 down votes
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Goal 3: Advance Translational Research

ASCVD Risk and Treatment Options

There is little evidence about the best ways in which to effectively communicate atherosclerotic cardiovascular disease (ASCVD) risk to patients so that they clearly understand the potential benefits and harms of treatments in order to make informed decisions about their care. A shift toward shared decision-making and tailored treatment makes it imperative that effective risk communication strategies be developed and... more »

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-2 net votes
6 up votes
8 down votes
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(@dstrickland) kudos icon +

Goal 3: Advance Translational Research

Molecular determinants of vascular wall development and aneurysm formation that can be used as markers for early diagnosis

To increase the potential of translating basic research discoveries into the clinic, there is a need to discover molecular biomarkers that confer risk for aneurysms and vascular dissections. The creation of a nation-wide biorepository of well-defined tissue and plasma samples along with research utilizing these tissue samples employing state-of-the art proteomics, genomics and development of appropriate mouse models will... more »

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5 net votes
7 up votes
2 down votes
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Goal 3: Advance Translational Research

Developing a Research Community for T4 Translation Research

What incentives will encourage current and new NHLBI investigators to pursue late translation (T4) research of proven effective interventions in heart, lung, blood, and sleep diseases?

One of NHLBI’s current strategic plan’s goals is to translate discovery and early translation research knowledge to late stage T4 translation for use in populations so that it has significant positive health impacts and provides a return... more »

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-3 net votes
8 up votes
11 down votes
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Goal 3: Advance Translational Research

Risk Mitigation of Implantable Cardiovascular Devices

There is a serious need to improve implantable cardiovascular devices to eliminate, or at least substantially reduce, the risk of serious adverse events from occurring to more effectively treat patients.

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-14 net votes
9 up votes
23 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 3: Advance Translational Research

Expediting Gene and Cell Therapies to the Clinics

What methodologies will best enhance the translation of technologies for gene and cell therapies into potential products for clinical application and commercial development?

In considering a strategy for NHLBI investment in gene therapy, it is important to note that we are only at the beginning of a revolution that will eventually impact biomedical research across a broad range of specialties. NHLBI/NIH needs to create... more »

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66 net votes
97 up votes
31 down votes
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