(@ewong0) kudos icon +

Goal 3: Advance Translational Research

Development of Novel Apheresis Adsorption Technologies to More Effectively and Safely Treat Hematologic Diseases

Current FDA approved apheresis technology currently uses elutriation/centrifugation separation techniques to remove pathologic cellular and/or plasma elements. These techniques are non-specific, limited by inefficient removal kinetics and often require considerable blood product exposure. Despite tremendous improvement in our understanding of the pathophysiology of a variety of disease, our ability to treat many of... more »

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93 net votes
112 up votes
19 down votes
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(@lholmber) kudos icon +

Goal 3: Advance Translational Research

What is the best time to undergo a stem cell transplant (HCT)?

In this era of all the new therapies in cancer treatment, I believe stem cell transplants run the risk to be delegated to be used as last ditch effort to treat patients when all other therapy fails. Historically this has not been the group that benefitted the most from a transplant. I believe that better national studies need to be designed and funded to address the optimal use of transplant to benefit our patients... more »

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47 net votes
78 up votes
31 down votes
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(@kkomanduri) kudos icon +

Goal 3: Advance Translational Research

How can we develop more selective immunosuppression for allogeneic hematopoietic cell transplantation?

Graft versus host disease (GVHD) remains the most significant complication of allogeneic hematopoietic stem cell transplantation (HCT). While the use of HCT has grown significantly safer and has demonstrated broad efficacy in the setting of a broad range of blood diseases, immunosuppressive therapy has not dramatically evolved since the introduction of calcineurin inhibitor-based approaches decades ago. The availability... more »

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106 net votes
129 up votes
23 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 3: Advance Translational Research

Improve patient compliance through community health workers

What are effective strategies for community-based participatory dissemination and implementation research initiatives in rural settings?

• Limited number of studies that adapt evidence- or practice-based interventions to rural settings
• Needs innovative approaches to engaging the rural community
• New intervention approaches needs testing in rural communities
• Building a team would have to involve of local community... more »

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7 net votes
15 up votes
8 down votes
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(@njkenyon) kudos icon +

Goal 3: Advance Translational Research

Using "omics" technologies to define responders to drug therapies

Metabolomic and proteomic technologies open tremendous avenues to define at the systemic level and, in the case of the lung, the organ level response to drug and non-drug interventions. The concept of responders and non-responders to therapies is poorly defined and hampers development of biomarkers and appropriate animal models. Omics technologies can bridge these important areas. In lung disease, breath analysis could... more »

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7 net votes
13 up votes
6 down votes
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(@danny.bluestein) kudos icon +

Goal 3: Advance Translational Research

Greating grant mechanism for fostering collaboration with industrial partners

There is a disconnect between the cardiovascular devices industry and the basic research that is conducted in the field by biomedical engineering researchers. Technological solutions that the industry is converging to are not well informed by the advances in basic translational research. A distinct funding mechanism should be created for fostering such collaborations. To motivate for profit cardiovascular device manufacturers... more »

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1 net vote
9 up votes
8 down votes
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(@rjjones) kudos icon +

Goal 3: Advance Translational Research

Allogeneic transplantation as a safe and universally available therapeutic strategy for treating non-malignant blood diseases

Can new advances in allogeneic blood or marrow transplantation (BMT) make the procedure a safe and universally available therapeutic strategy for treating non-malignant blood and immune disorders such as sickle cell anemia, thalassemia, aplastic anemia, and severe combined immune deficiency?

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164 net votes
214 up votes
50 down votes
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(@wmars0) kudos icon +

Goal 3: Advance Translational Research

Microvascular Dementia

The catchword Alzheimer's Disease (AD) is used to describe almost all types of dementia these days, and a lot of work has gone into developing preventive and/or therapeutic interventions for AD, but studies show that 40% of "AD" patients may in fact have something else. Microvascular Dementia (MD) presents with a similar phenotype. Delineating these two entities and then developing treatment strategies for MD is my... more »

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8 net votes
16 up votes
8 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 3: Advance Translational Research

Developing adherence research to reduce unnecessary mobility/mortality/cost

From Cochrane Review NOV 20 2014
RB Haynes

“It is uncertain how medicine adherence can consistently be improved so that the full health benefits of medicines can be realized. We need more advanced methods for researching ways to improve medicine adherence, including better interventions, better ways of measuring adherence, and studies that include sufficient patients to draw conclusions on clinically important effects.”... more »

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5 net votes
7 up votes
2 down votes
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(@soldatovn.humgenex) kudos icon +

Goal 3: Advance Translational Research

Calcium channels in cardiovascular functions and diseases

Fifty years ago Prof. Harald Reuter of the University of Bern, Switzerland obtained the first experimentally supported evidence that the calcium channel is a physiologically distinct entity. Further stimulated by the synthesis of the dihydropyridine calcium channel blocker nifedipine, the field of calcium channel research rapidly encompassed cardiovascular and other powerful biomedical directions.

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-2 net votes
1 up votes
3 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 3: Advance Translational Research

Increased receptivity to probative programmatic trials

We believe there should be greater openness to large, simple trials that answer clear questions of interest (e.g. does giving children more fruits and vegetables while changing nothing else lead to weight loss?; does eating breakfast regularly lead to weight loss?; etc.). The conduct of such trials may sometimes be expensive but can sometimes be only modestly costly if they are kept simple. However, it is difficult to... more »

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0 net votes
1 up votes
1 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 3: Advance Translational Research

Application of data science to extract information from EHR/EMR

There is a need to utilize bioinformatics to analyze electronic health records / electronic medical records (EHR/EMR) documentation of practice-based pulmonary and sleep medicine to better understand longitudinal care delivery patterns and outcomes, identify changes in evidence, inform practice, and foster reverse translation to integrate basic and clinical research.

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54 net votes
81 up votes
27 down votes
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