Goal 4: Develop Workforce and Resources

Benefits to the US in funding global health research in LMICs

What are the benefits to the US in funding global health research in low-to-middle-income countries?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

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Non-communicable diseases (NCDs) are the leading cause of death and disability worldwide. The four leading NCDs are cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes. The most common risk factors are tobacco use, physical inactivity, unhealthy diet, and alcohol use. NCDs and risk factors are shared globally and offer many opportunities and benefits to US funders and academia, such as implementing treatments in under resourced populations that could benefit US under resourced populations; identifying effective treatment for diseases with low incidence and prevalence in the US; and expanding physician training by caring for patients with diseases in early stages that are not commonly seen in the US until they are quite advanced The United Nations recognized the NCD global burden and held a high-level meeting on NCDs September 19-20, 2011. NHLBI should consider increase funding of global collaborations between the US and LMICs to address this increasing global health burden. Funding for these collaborations would help merge the fields of communicable and non-communicable diseases and provide opportunities for HICs to adopt some of the successful health care interventions implemented in LMICs. NHLBI should also consider a strategy to better inform politicians and taxpayers about the importance and benefits of global NCD research and increase their funding for NCD programs at academic institutions to train young chronic disease professionals.

Name of idea submitter and other team members who worked on this idea Nancy Dianis

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Training in Small Molecule Discovery and Development

The current generation of heart,lung, and blood investigators are not equipped with competitive training needed to approach, design, and test appropriately small molecule therapeutics that may move through the FDA pipeline. Appropriate in silico ligan or structure based design, HTS, design of Pd/Pk models, "go-no-go" branchpoints in drug development, screening approaches, and drug target validation are issues that are... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

The incorporation of workshops, traditional funding mechanisms (T32, F32 etc) earmarked for this type of training will help position and equip NHLBI investigators to more effectively navigate through the landscape of drug discovery and development.

Name of idea submitter and other team members who worked on this idea Rama Mallampalli, MD

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Similar changes to those in modern manufacdturing are required through our new technical society inlcuding medicine.

Attitudes to Mistakes. Changing prescription and protocol philosophy.
As an older patient, I am 89, I have one thing many others do not have, experience. As an engineer with much experience in manufacturing industry I have seen great recent changes in manufacturing sociology. Now, even top management comes to listen to “the Gemba” (the shop floor) and what could be regarded as mistakes are seen as opportunities to improve... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

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As an engineer with considerable experience in manufacturing industry I have seen great changes in manufacturing sociology. We have come to listen to the Gemba (the shop floor) and inappropriate procedures are now regarded as opportunities to improve not something to be punished. Perhaps I can mention that my writing has been praised on this subject, for example for the book, "The Puritan Gift” by Kenneth and Will Hopper. “This is one of the best books I have ever read in my long life, and I don’t just mean books on business” Foreword: by Russ Ackoff, Wharton Business School. “late in their lives (the Hoppers) have given us an extraordinary gift” (translated from Chinese) Promise Hsu, Vista Magazine

Feasibility and challenges of addressing this CQ or CC

I suggest as a subject for discussion, that a change to a more aggressive use of antibiotics could save antibiotics. There is an old saying that the best time to hit a man is when he is down. The same surely applies to harmful bacteria.

Name of idea submitter and other team members who worked on this idea Kenneth Hopper

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Training Mentors and Protégés to create a T4 translation pipeline

How can training of investigators (both mentors and trainees) be supported to create a T4 translation research pipeline?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Details on the impact of addressing this CQ or CC

A robust global T4 translation research community would be developed that would help translate proven-effective interventions for use in populations for a positive health impact

Feasibility and challenges of addressing this CQ or CC

The NHLBI Global Health and Health Inequities Think Tanks identified T4 translation research as an important area that needs development in the very near future.

However, conducting high quality T4 research requires a research community focused in this area. Currently, very few researchers are working in this area. The T4 research community needs to be identified so capacity can be established for conducting T4 research. Incentives would need to be developed to maintain a robust global T4 research community.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

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Goal 4: Develop Workforce and Resources

Basic and Clinical Multi-disciplinary Partnerships to Understand Lung Disease

Basic scientists and clinicians have different training and bring different perspectives to lung disease research. Additionally, mechanisms that facilitate interactions of scientists from different fields may improve communication and facilitate novel ideas for lung disease research. I would like to see a funding mechanism that encouraged such partnerships in addressing fundamental disease questions and/or treatments.... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

This mechanisms could bring more perspectives to bear on questions in lung disease and would facilitate multi-disciplinary interactions and ideas.

Feasibility and challenges of addressing this CQ or CC

If single awards, budgets would need to be large enough to allow for funding basic science as well as providing dollars to collect clinical samples. It should be possible to support some core facility infrastructure if needed and allow a budget that could account for basic scientists, animal work, study coordinators, clinicians, etc. Perhaps the RFA could require at least 3 different fields to be represented to try to facilitate multi-disciplinary approaches. Such a mechanism could help replace the loss of grants like SCOR grants and PPGs.

Name of idea submitter and other team members who worked on this idea Beth Moore

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Leveraging support from local institutions

Create a "Center of Excellence" designation in Cardiovascular Research akin to NCI's Comprehensive Cancer Center designation. Specific qualifications for such a designation will need to be defined. However this will encourage institutions to invest heavily in CV research to support such designation. In this way, local institutions will partner with NHLBI to support discovery in heart and vascular research.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

this will raise awareness of cardiovascular disease as a strategic area of investment for academic and private institutions. It would educate patients and encourage them to participate in compelling clinical trials in respected and trusted institutions. It would cause institutions to strive for excellence in research.

Name of idea submitter and other team members who worked on this idea David Gutterman

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Productivity of established investigators

Maintaining and increasing the productivity of established investigators. Increase overall funding for R awards and their duration and reduce administrative burden.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea Society for Vascular Surgery

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Shall we increase the transparency of the grant review process to prevent potential biases?

Financial and intellectual conflict(s) of interest are common in academic medical sciences. Those conflicts could potentially bias decisions of study section members and change grant application outcomes. During the grant review process, financial and/or intellectual conflict(s) of interest disclosures of the study section members are not readily available to the grant applicants or the public. Should the NHBI increase... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

Increased transparency in the grant review process will provide a more plain level field for all applications, including new investigators with novel ideas.

Feasibility and challenges of addressing this CQ or CC

Public disclosure of financial (more than intellectual) conflict(s) of interest are becoming the standard in medical societies and scientific publications.

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What should mentors report?

There is a need to establish markers that are predictive of future trainee success.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

Instructions to Mentors for K Awards and Sponsors for F awards for reporting on the progress of their trainees in RPPR non-competitive renewal applications are very general. Developing more specific criteria and rankings should better predict future stars. Having more explicit training criteria throughout the life of a program could improve the overall quality of the mentoring and the training within the program.

Feasibility and challenges of addressing this CQ or CC

Five to ten years is sufficient time to track a representative sample of programs to develop criteria to be tested.

Name of idea submitter and other team members who worked on this idea NHLBI Staff

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Education in glycobiology is nearly non-existent

Aside from a handful of locations around the country, there are no local opportunities for the vast majority of PhD students to learn about glycobiology. A search on NIH Reporter for T32 grants with "glycobiology” reveals two grants (one NCI for cancer cell biology, one NIGMS for pharmacology). Neither of these grants are focused upon glycobiology. In fact, glycobiology is essentially never integrated into any standard... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Feasibility and challenges of addressing this CQ or CC

I have participated in the American Association of Immunologists Advanced Course in Immunology the past several years. I give a single 90 minute lecture on “glycoimmunology”. While this helps to plant the seed of interest in how glycans impact the immune response and host defense, it is not nearly enough. I suggest the following ideas to begin closing this gap in training:

  1. Support glycobiology training grants (T32) throughout the country, and not just at the small number of institutions (Emory, UCSD, UGA/CCRC, Johns Hopkins) with existing strength; and 2. Provide an incentive to integrate glycobiology aspects into other T32 proposals targeting the NHLBI to improve integration of the field into the broader context.

An important point, however, is that outside of the institutions already mentioned, existing glycobiology training opportunities are rare due to a lack of support. Thus, the NHLBI must be willing to help seed nascent training programs through a targeted funding initiative. As a PI of an immunology-focused T32, it is clear to me that competition for a ‘standard’ T32 in glycobiology would be impossible within the standing CSR T32 panel.

Name of idea submitter and other team members who worked on this idea Brian Cobb

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Goal 4: Develop Workforce and Resources

Make PhD Career Paths More Transparent

A critical challenge will be making career paths transparent to prospective PhD students and postdocs. At present, few departments, programs and institutions are collecting and making readily available any credible data about the career experiences of their past graduates. To be useful, such data should address at least five years of post-PhD career experience; shorter-term data is likely to be dominated by postdoctoral... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

Provide credible information to prospective PhD students and postdocs, so that they have good information about career paths and trends before they decide what to do after earning their first degrees.

Feasibility and challenges of addressing this CQ or CC

Most PIs know what their former PhD students and postdocs are doing, but such information is rarely compiled by departments and programs.

Name of idea submitter and other team members who worked on this idea Michael S. Teitelbaum

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Ask Dr. Hsia to stop littering the forum to advertise his company

True dialogue is impeded by having to constantly scroll through a repeated posting of the same company advertisement. This is abuse of the forum.

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

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Comment by chsia 05/05/2015
Dear All,

  1. Nano Red Blood Cell (NanoRBC) can be used alone or used conjunction with banked blood to improve the potency and safety of transfusable red blood cells.

etc.

Sincerely,

Carleton Hsia, Ph.D.
Chairman&CEO
NanoBlood LLC

Feasibility and challenges of addressing this CQ or CC

Press Release
FOR RELEASE: Thursday, April 28, 2015
Contact: Natalie Likness, Governor’s Office of Economic Development, 605.773.3301
NanoBlood LLC Relocating to South Dakota

SIOUX FALLS, S.D. – NanoBlood LLC, based in Irvine, Calif., announced today that it is relocating to the South Dakota Technology Business Center (SDTBC) in Sioux Falls, S.D., to continue the regulatory and commercial development of its nano red blood cell as a life-saving drug in critical care and transfusion medicine.

etc.

“I am very grateful and appreciative of Gov. Daugaard’s support of commercial development of nano red blood cell in South Dakota for domestic and global need in critical care and transfusion medicine,” said Carleton Hsia, chairman and CEO of NanoBlood.

Name of idea submitter and other team members who worked on this idea none

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Which factors are associated with systems performance?

What are the institutional factors, including structure and culture of care, that characterize systems performance? Which of these factors are potentially modifiable and/or scalable?

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea AHA Staff & Volunteers

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Goal 4: Develop Workforce and Resources

Align PhD Content with Careers Available to Recent PhDs

There is a need to create better alignment between the content of biomedical PhD programs and the careers that actually are available to those who have earned PhDs. Though available data are surprisingly weak, all the evidence suggests that only a small fraction (perhaps 15%) of current biomedical PhDs and postdocs are likely to find stable careers in academic research. Larger proportions are more likely to be employed... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea Michael S. Teitelbaum

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Enhance funding for population and public health research

Many challenges posted here focus on increasing translation and development of interdisciplinary teams. Diverse backgrounds and epidemiological training makes population and public health scientists ideal candidates to connect teams in different areas of research around translation to human health. While funding exists specifically for career development of physician and pre-clinical scientists, none exists for epidemiologists.... more »

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? Critical Challenge (CC)

Details on the impact of addressing this CQ or CC

NHLBI is currently investing heavily in training epidemiologists at the PhD and postdoctoral level, but may be losing those researchers during the transition to independence and mid-career stages. Compared to those with clinical backgrounds or basic science skills, PhD epidemiologists rarely have alternative resources to fall back on when NIH funding is reduced and may have less interest in joining industry if their primary research interest is improving public health at the population level. This may make epidemiologists particularly vulnerable to leaving the field of health research. Dedicated funding that prioritizes human studies and population level research would help retain well-trained epidemiologists whose primary dedication is to improving chronic disease outcomes.

Feasibility and challenges of addressing this CQ or CC

While the current level of funding is a challenge to everyone working in science right now, adding funding mechanisms specifically for epidemiology like those that already exist for clinician scientists and pre-clinical research could play an essential role in maintaining the pace of innovation and implementation of research.

Name of idea submitter and other team members who worked on this idea Morgana Mongraw-Chaffin

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