Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.
(@mariannes.clancy)

Goal 1: Promote Human Health

Endoglin Regulates biolgy and signal transduction in vascular smooth muscle cells

Why loss of endoglin causes HHT is not known. Endoglin is expressed by vascular smooth muscle cells and endothelial cells.

What is the role of endogin on vascular smooth muscle cells and why its loss contributes to HHT and other vascular malformations

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1 net vote
1 up votes
0 down votes
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(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Extreme makeover: harnessing adaptation mechanisms for therapy

What extreme adaptive physiological mechanisms in heart, lung, and blood systems might have the greatest potential to be targeted or employed in therapeutic strategies? Human physiology, including the heart, lung and blood systems, is known to possess extreme adaptive mechanisms to counter extreme conditions or unusual situations. Although some studies are being done, many of these mechanisms have not been fully explored... more »

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-4 net votes
8 up votes
12 down votes
Active
(@nhlbiforumadministrator1)

Goal 1: Promote Human Health

Studying Health in Addition to Disease

Why do some people stop smoking after a stroke or myocardial infarction, whereas others do not? What motivates people who adopt a healthier diet and exercise program during their lifetime or after a significant health event? How can we promote healthier lifestyle choices at all stages of life? How do we ensure equitable health promoting activities for minorities, vulnerable populations, and lower socio-economic status... more »

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135 net votes
176 up votes
41 down votes
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(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Reporting disaggregated data by sex

There is a need to better understand the biological basis for sex differences, particularly for identifying important basic factors that influence normal cardiovascular function and cardiovascular disease in males or females and explain differences in the overall prevalence, progression, and mechanism of cardiovascular disease.

Voting

8 net votes
13 up votes
5 down votes
Active
(@gaynor)

Goal 1: Promote Human Health

Improving longterm outcomes after surgery for congenital heart disease

Survival has improved but neurobehavioral disabilty remains a common complication with adverse impacts on quality of life, educational and occupational attainments, and resource utilization. There is increasing evidence that brain development is abnormal, and leads to a rrisk of peri-operative brain injury.

Studies are needed to;
1. Further define the prevalence and spectrum of neurobehavioral disability.
2, Understand... more »

Voting

18 net votes
23 up votes
5 down votes
Active
(@churv0)

Goal 1: Promote Human Health

Simplify cancer survivor followup

Excellent work has been done by Childrens Oncology Group and Childhood Cancer survivor group and the late effects of cancer treatment ,especially in children but also young adults is an ongoing field of study. However protocols for follow up studies ,which should be done and how often and by whom are very complicated and hard to follow.
My idea is to develop a simple, relatively inexpensive and user friendly,protocol... more »

Voting

4 net votes
10 up votes
6 down votes
Active
(@wheeze)

Goal 1: Promote Human Health

Environmental Exposures and Atopic Disease

As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:

 

What are the molecular and cellular responses in the lung that occur after environmental stimuli (including allergens) that predict homeostatic resilience or transition to atopic diseases?

Voting

-7 net votes
8 up votes
15 down votes
Active
(@nhlbiforumadministrator)

Goal 1: Promote Human Health

New Approaches to study interactions of blood cells with components of the vascular wall

To eventually modulate pathologic communication processes employing new therapeutics, there is a need to better understand the transcellular communication between blood cells and components of the vascular layer in vivo.

Voting

15 net votes
25 up votes
10 down votes
Active
(@psaty0)

Goal 1: Promote Human Health

What administrative changes might facilitate team science? Update peer-review and budget mechanisms for team science.

NIH peer-review methods were developed at a time when biomedical science was generally conducted by individual investigators. Approaches to defining conflict of interest in peer review that worked well for individual investigators may not be fit for the review of large-scale collaborative projects. Similarly, the subcontract mechanisms are often slow and cumbersome at a time when projects need to be nimble and timely.... more »

Voting

54 net votes
74 up votes
20 down votes
Active
(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Host and environmental factors effect on transplantation biology and regenerative medicine

How does inflammation and cell injury induce the immune system during transplant rejection? How do we control immune responses to enable cell- and tissue-regenerative strategies?
• How does inflammation and cell injury induce the immune system during transplant rejection?
• How do we control immune responses to enable cell and tissue regenerative strategies?
• How do we use iPS cell based and gene editing based therapies... more »

Voting

34 net votes
48 up votes
14 down votes
Active