(@rosemarie.robertson) kudos icon +

Goal 1: Promote Human Health

Investigating Co-Morbidities in Women's Cardiovascular Health

There are important questions related to the cardiovascular health of women, and particularly to diagnostic and therapeutic challenges arising from the common existence of co-morbid conditions. The latter consideration, as well as the limitations of the budgets of individual institutes and centers at the NIH, suggest that it may be reasonable for the NHLBI to consider cross-NIH collaborations with I/Cs that have related... more »

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(@baz200) kudos icon +

Goal 1: Promote Human Health

Obesity and Morbid obesity

Obesity is a pervasive disease. It contributes to serious diseases such as heart, all the way down to cancer. In the past five decades it has been confirmed that the sugar from rich carbohydrate (CHO) foods increases the production of insulin which in turn converts the excess caloric intake into fat. So far neither dieting with highly processed foods rich in CHO’s, nor radical surgery have made a dent in this most... more »

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(@anna.adachimejia) kudos icon +

Goal 1: Promote Human Health

smoking cessation in rural and special populations

We are concerned about access to smoking cessation programs in populations that are hard to reach (rural) and who have other challenges (underserved/marginalized populations including people with serious mental illness). What kind of computer-based or mobile health technologies can assist these groups?

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(@churv0) kudos icon +

Goal 1: Promote Human Health

Simplify cancer survivor followup

Excellent work has been done by Childrens Oncology Group and Childhood Cancer survivor group and the late effects of cancer treatment ,especially in children but also young adults is an ongoing field of study. However protocols for follow up studies ,which should be done and how often and by whom are very complicated and hard to follow.
My idea is to develop a simple, relatively inexpensive and user friendly,protocol... more »

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(@media0) kudos icon +

Goal 1: Promote Human Health

THE RELEVANCE OF PREVENTION TRIALS

Prevention trials, implemented to reduce or delay progression to overt disease in a population at risk to the disease, are an important approach to health promotion.
Therapies shown to reduce disease severity in patients with a specific disease are obvious, but not the only, candidates for a prevention trial in populations at high risk for prevalent diseases (such as heart failure, diabetes, COPD, asthma in children).... more »

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(@mtseng) kudos icon +

Goal 1: Promote Human Health

Improve understanding of cardiometabolic health in Asian Americans

We are only now beginning to recognize that certain Asian American subpopulations are at high risk for cardiometabolic (CM) disorders thanks to recent ethnicity-specific studies (e.g., MASALA study). For the most part, however, our understanding of CM risk in Asian Americans is based on aggregated data. Further, a perception remains that other, understudied groups (e.g., Chinese Americans) are at low risk because of their... more »

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(@jlaakso) kudos icon +

Goal 1: Promote Human Health

Examining the interface between physiological and pathophysiological angiogenesis and placental function in at risk pregnancies.

Abnormal placental function, characterized by retarded nutrient and oxygen exchange, and abnormal hormone and angiogenic growth factor production, is linked to a number of diseases that have a strong impact on maternal and fetal health. Perhaps of highest impact is pre-eclampsia, a disease affecting 5-8% of pregnant women worldwide. Moreover, issues related to a suboptimal intrauterine environment leading to growth... more »

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(@mariannes.clancy) kudos icon +

Goal 1: Promote Human Health

Endoglin Regulates biolgy and signal transduction in vascular smooth muscle cells

Why loss of endoglin causes HHT is not known. Endoglin is expressed by vascular smooth muscle cells and endothelial cells.

What is the role of endogin on vascular smooth muscle cells and why its loss contributes to HHT and other vascular malformations

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