It is beginning to be known that malignant cells interact with neighboring cells and the course of their malignancy is directed by those cells. It is also known that transplanted stem cells interact with nearby cells and acquire direction of maturation and cell type from those cells. In my experience in unpublished work, the nature of the materials that leukocytes and monocytes have encountered during their apheresis... more »

Understanding basic mechanisms for intravascular triglyceride metabolism

Congress doesn't seem to "get it" regarding the return on investment for biomedical research, but maybe the public does. Create a mechanism whereby individuals can donate directly to the NIH to support research in specific areas (or provide general support).

What is the connection between the gut microbiome and the development of hypertension?

There are not enough large data sets available for researchers to study young and aging patients with congenital heart disease (CHD). There is a need to develop a low cost, high impact, large data collection initiative.

Endothelial cells derive from cells in the bone marrow. Circulating precursor endothelial cells contribute to newly forming vessels.

Do Alk 1 and/or Endogln mutations affect the functions of these cells once they incorporate into growing vessels. These vessels then go on to form arteriovenous malformations

What is the measureable normal human variation at the -omic, cellular, organ, and system levels within the population and across the lifespan?
• What are the range of normal human cellular functions that create resilience at all levels—cells, organs, organ systems?
• What inter-organ, tissue, and cellular communications maintain individual health and the health of populations?
• How do we understand why individuals with... more »

What is the effect of donation-induced iron deficiency on blood donor health?

Individuals differ substantially in their physiological, health, behavioral and cognitive responses to sleep loss. Although these differences represent a trait, individuals who are vulnerable in one domain may be resilient in another - few systematic relationships between physiological, long-term health, cognitive and subjective responses to sleep loss have been found. Moreover, within a given domain, vulnerability to... more »

What are the best tools/algorithms for robust and objective evaluations of sleep health biomarkers?

Understanding normal aging

The scientific and clinical ramifications of the transulfurization systems are just beginning to be explored. Research methods and hypotheses should be explored.

There is a need to create tools to access and analyze electronic medical records (EMR) data and its linkage to “omics.”

What is necessary to reprogram the immune system to improve transplant outcomes of hearts, lungs, and hematopoietic cells? While NIAID is a major funder of immunology research, we are a major contributor to stem cell research. Our resources could be combined, where NIAID would support this approach for autoimmune diseases, and we would support work in tolerance for transplants.
If the NCI also wants to collaborate on... more »

What are the long-term health outcomes on victims and/or family members whose male children have been victimized or murdered during encounters with police officers?