(@robert.paine) kudos icon +

Goal 3: Advance Translational Research

Understanding heterogeneity in ARDS

ARDS is a syndrome, yet we treat it as though it was a single clinical disease. There has been success in improving the process of care for patients with ARDS, but no real progress on address the underlying process. For successful therapies to influence the disease process, we need to be able to distinguish the mechanisms active in individual patients and so that we can design and test interventions targeting the specific... more »

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Goal 3: Advance Translational Research

Advancing the science of translating evidence into practice

What are the best ways for the NHLBI to advance the evolving science of translating robust evidence into clinical practice domestically and globally? How to personalize broad research evidence for individual patients?
How to predict and evaluate the impact of evidence-based interventions?
How to identify implementation methods available in industry and elsewhere that work best and are most translatable in healthcare?... more »

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(@xuejunparsons) kudos icon +

Goal 3: Advance Translational Research

Deriving Cardiac Elements from Pluripotent Human embryonic Stem Cells for Heart Reconstitution

to date, the existing markets lack a clinically-suitable human cardiomyocyte source with adequate myocardium regenerative potential, which has been the major setback in developing safe and effective cell-based therapies for regenerating the damaged human heart in cardiovascular disease.

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Goal 3: Advance Translational Research

Engineering Challenges for Next Generation VADs

Critical challenges to overcome include the development of non-platelet activating impellers and hypothrombogenic surfaces in modern ventricular assist devices (VADs). Percutaneous and transcutaneous electric drive systems will need to evolve, and clinical research is needed to reduce thromboembolism and bleeding (acquired von Willebrand syndrome). Adverse events may also be further reduced if smaller pumps, for partial... more »

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(@gwilliams) kudos icon +

Goal 3: Advance Translational Research

Infrastructure for human translational research

With the reduction in NCAT support for human translational research, infrastructure support will need to come from the NHLBI. This will increase the cost of most human, mechanistic based RO1 studies by 20-30%. This will exceed the current cap of $500K in many circumstances. The cap will need to be raised or NHLBI and other institutes need to determine how NIH can continue to provide this critical infrastructure.

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(@mnicolls) kudos icon +

Goal 3: Advance Translational Research

Developing animal models of lung transplantation.

Lung transplantation as a cure for terminal lung disease has seen little improvement in outcomes for more than 20 years. The field remains highly challenging, in part, because of an absence of robust animal models which are technically- feasible and reproducible across centers. Further, models have limited relevance to clinical (chronic) airway remodeling, the leading problem in pulmonary allografts. In the absence of... more »

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Goal 3: Advance Translational Research

A Pipeline for Investigator- Initiated Translational Science

How might the NHLBI effectively encourage and support its investigators to collaborate with strategic partners to pursue the early translation of their HLBS discoveries into new diagnostics and therapeutics?

The critical challenges to effective early translation of discovery science experienced by the investigator community include:

1. The need for translational skills development, training and guidance

2. Need for... more »

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Goal 3: Advance Translational Research

Healthcare Inequity

Many continue to pay higher benefits for less care. Often they are seniors who do not need OB/Gyn or pediatric benefits, etc. They are not covered for eyeglasses, dental work, etc. Those covered under Obama care plans and subsidies are entitled to more care. Now states are legalizing recreational drug use, same sex marriage, etc.
Why? It is only logical to realize this will place more unnecessary burden on the already... more »

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Goal 3: Advance Translational Research

Build a National Surveillance of Chronic CV and Lung Diseases

There is a need to build a robust coordinated surveillance system on the incidence and prevalence of chronic diseases. Surveillance data are needed to:

•Describe and monitor the burden, trends, and patterns of these diseases

•Set parameters and metrics of research priorities

•Identify where to target resources for prevention, treatment, and delivery of care

•Track and monitor progress toward public health disease... more »

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13 up votes
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(@soldatovn.humgenex) kudos icon +

Goal 3: Advance Translational Research

New funding mechanism for major diseases

According to the National Bioeconomy Blueprint" published in 2012 by the White House Office of Science and Technology Policy, “Flexibility in the use of new and existing funding mechanisms in and across agencies will be vital to stimulating the discovery of new bioinventions with potential to grow the bioeconomy” (p. 24).
It is known that the most effective research program in American history was the Manhattan Project.... more »

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