Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.
(@wheeze) kudos icon +

Goal 1: Promote Human Health

Environmental Exposures and Atopic Disease

As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:

 

What are the molecular and cellular responses in the lung that occur after environmental stimuli (including allergens) that predict homeostatic resilience or transition to atopic diseases?

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-7 net votes
8 up votes
15 down votes
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(@glancast) kudos icon +

Goal 1: Promote Human Health

Updating level C evidence in Clinical Guidelines

Clinical Guidelines depends on good science. Despite this, only 11% of guidelines that reported level of evidence in 2009, had level of evidence A while 48% had level C. Studies have shown that recommendations based on Level of Evidence C (or their equivalence) are significantly less reliable and may be downgraded, reversed or omitted when better evidence is available.
I propose a comprehensive review of ACC/AHA... more »

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3 net votes
3 up votes
0 down votes
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(@jimandmarynelson) kudos icon +

Goal 1: Promote Human Health

Funding of Stem Cell/Lung Regeneration Research

How to "cure" a chronic, incurable disease - A potential giant step in saving the lives of many thousands of Americans, and potentially millions worldwide, who are afflicted with COPD, the third leading cause of death in the U.S.
The financial effect of COPD in the United States alone is well over $50 billion per year. It is estimated that some 30 million Americans have COPD, which of course means that at least that... more »

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25 net votes
32 up votes
7 down votes
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(@dayam0) kudos icon +

Goal 1: Promote Human Health

Non-opioid management of pain

The use of opioid agents has increased dramatically in the United States. Prescription drug overdoses now account for more deaths than traumatic injuries in the 1-44 age group. There is a need for more high level evidence to target optimal pain management strategies in the acute (ED) and non-acute settings (office practice) especially for chronic disorders such as low back pain, headaches, fibromyalgia, acupuncture etc.... more »

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6 net votes
6 up votes
0 down votes
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(@paulbrookes) kudos icon +

Goal 1: Promote Human Health

Adult Cardiomyocytes in Culture

So much basic cardiovascular discovery relies on cell culture models. While cardiac cell lines exist (e.g. HL-1, H9c2), these often poorly model aspects of cardiomyocyte function in-situ (e.g. contractile function, metabolism). In contrast, primary cardiomyocytes isolated from adult animals (especially mice!) are not readily amenable to culture conditions. Even if cells can be kept alive, they are often refractory to... more »

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-25 net votes
12 up votes
37 down votes
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(@nhlbiforumadministrator1) kudos icon +

Goal 1: Promote Human Health

Cardiac Engineering – Deciphering the Cardiome

To maintain cardiac health and prevent disease, there is a need to decipher the cardiome of cells and genes and use this knowledge (1) to better understand cardiac structure and function and (2) to engineer systems on the level of organs, organ systems, and the entire individual.

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-16 net votes
10 up votes
26 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 1: Promote Human Health

Global cohorts to fill gaps in knowledge

Given the global burden of disease, what does NHLBI plan to do to establish a diverse global cohort to connect basic sciences to population health, in a way that differences in phenotypes around the world can be studied rapidly? For example, why not start by supporting a coalition of cohorts originally funded by the Global Heart Initiative?

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-8 net votes
5 up votes
13 down votes
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(@sjk000) kudos icon +

Goal 1: Promote Human Health

Theoretical division of NHLBI

Many functional physiology, cellular physiology , electrophysiology, and other aspects are amenable to rigorous mathematical methods.NHLBI lacks a theoretical division where IDEAS expressed mathematically make testable predictions at multi scale levels.


NHLBI LACKS A THEORETICAL DIVISION- although history has shown that virtually all original ideas have a mathematically expressible foundation, particularly when dynamic,... more »

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-13 net votes
12 up votes
25 down votes
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(@nhlbiforumadministrator1) kudos icon +

Goal 1: Promote Human Health

Smart Biomaterials for Self-Adjusting Implants

There is a need to leverage ongoing research on active materials (e.g., self-regenerating body armor, insulin-releasing polymers that respond to glucose, etc.) to stimulate the invention of new materials and constructs that are electrically, chemically and mechanically active to enable self-adjusting bioengineered implants.

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-4 net votes
9 up votes
13 down votes
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(@katiebecofsky) kudos icon +

Goal 1: Promote Human Health

Establishment of a Human-Animal Interaction (HAI) research program at NHLBI

NICHD has a human-animal interaction (HAI) research program dedicated to advancing knowledge of the health benefits and therapeutic uses of animals for children, but no comparable program exists for NIH research with adults. As many of the potential health benefits/therapeutic uses of companion animals relate directly to cardiovascular health (e.g., increased physical activity, reduced stress, reduced loneliness), NHLBI... more »

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-14 net votes
7 up votes
21 down votes
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