2. Combination therapy vs monotherapy for pneumonia due to Pseudomonas. This is another major area of contention – for nearly 2 decades, and generates... more »
Will adaptive trial design improve clinical research for acute lung injury?
Is FVC a valid surrogate for mortality in patients with idiopathic pulmonary disease?
Do the non-pharmacological interventions of pulmonary rehabilitation and supplemental oxygen for exertional hypoxemia improve quality of life and functional status in patients with chronic fibrotic ILD?
What is the natural history of the best characterized ChILD disorders (surfactantrelated sequence variants, neuroendocrine cell hyperplasia of infancy (NEHI),pulmonary interstitial glycogenosis (PIG),idiopathic pulmonary hemosiderosis)?
What is the relationship of ChILD disorders to adult diffuse lung disease?
What is the relationship of ChILD disorders to more common childhood respiratory diseases?
What is the relationship of ChILD disorders to other clinical populations that manifest ILD?
a) How can we improve the prediction of which lung transplant recipients are at greatest risk for nonadherence?
b) What are the most efficient and effective ways of assessing nonadherence in the clinical setting?
c) Conduct clinical trials of... more »
a) Conduct clinical trials of interventions designed to maximize clinicians' support of patients' self-management... more »
Does "goal-targeted" therapy (with adjustments/additional therapy, if certain "goals" are not achieved) improve quality of life, functional status, and survival in patients with pulmonary arterial hypertension? Trials of therapies for hepatopulmonary syndrome.
Does pulmonary rehabilitation or regular exercise improve outcomes in patients with PVD?
Does the treatment of gastroesophageal reflux disease improve outcomes in patients with IPF?