Can novel therapeutics including cell-based therapy be tested in patients with severe acute lung injury (P/F <200) and shock (need for vasopressors) since these are the patients with the highest mortality (> 30%) based on NHLBI ARDS Network data?

Can novel extracorporeal devices that remove carbon dioxide be tested to limit or avoid positive pressure ventilation in patients with acute respiratory failure from COPD?

Will adaptive trial design improve clinical research for acute lung injury?

Many pharma companies are developing inhaled antibiotics for patients with bronchiectasis, recognizing the increasing market (over 110,000 patients in the US). These drugs cost thousands of dollars per year and will be heavily marketed and heavily used, as there are limited options for these patients. It is unknown if rotating oral antibiotics (cost is a fraction of the inhaled ABx) would yield similar results.  A Cochrane... more »

What are the best methods for NHLBI to contribute to reforms that make careers more attractive to people from disadvantaged backgrounds?

What are the best methods to identify future training areas and develop/adapt training and mentorship programs to address future critical needs?

Are T32s doing a sufficient job of promoting interdisciplinary and team science? Should we change the way these programs are structured?

What can research institutions do to entice and support potential and actual K award applicants to become independent scientists?

To ensure continuity of mentorship across generations, should we create incentives to encourage participation of younger, junior faculty in the leadership of our T32 programs?

We need to increase our base of T4 implementation research expertise among researchers, reviewers, and investigators.

What kinds of incentives, reforms, and exposures would work best with students from diverse and disadvantaged backgrounds to pursue careers in science?

There is a critical challenge to retain highly trained basic and clinical scientists in the biomedical research enterprise and expediently promote their independence and capacity to produce innovative discoveries. There is a need to provide more funding opportunities for collaborative, team-science approaches to scientific investigation by interdisciplinary teams comprised of clinician scientists, basic researchers, and... more »

What is the best way for the mentoring effort of senior investigators to be encouraged, enhanced, and supported to develop early career investigators?

There is a need to develop training programs, mentorship, and collaborations that cross boundaries and prepare researchers for future transdisciplinary needs.

How do we add communication skills to our training programs to improve scientists’ communication with the public?