Showing 22 ideas for tag "biology"
(@janssen.10)

Goal 3: Advance Translational Research

Human Heart Systems Biology

In the human failing heart, it is the systems biology that ultimately fails: electrical, mechanical, and chemical perturbations in their function do not manifest in isolation, but critically impact on each other in health and disease. Investigation of human myocardium, unlike inbred rodent models, is challenging since no two humans are identical. There is a need for the collection and assessment of clinical patient data,... more »

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6 net votes
13 up votes
7 down votes
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(@jnoel0)

Goal 2: Reduce Human Disease

UNDERSTANDING SLEEP AND CIRCADIAN DISORDERS AT A BASIC MECHANISTIC LEVEL

We need to understand sleep and circadian disorders at a more mechanistic level. This applies to both the pathogenesis of these disorders and to their impact on health. New neurobiological and molecular tools facilitate this research. The focus needs to be not only in brain but also the impact of these disorders on future of peripheral organs. The elucidation of the fundamental functions of sleep and the impact of... more »

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179 net votes
232 up votes
53 down votes
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(@nhlbiforumadministrator1)

Goal 1: Promote Human Health

Cardiac Engineering – Deciphering the Cardiome

To maintain cardiac health and prevent disease, there is a need to decipher the cardiome of cells and genes and use this knowledge (1) to better understand cardiac structure and function and (2) to engineer systems on the level of organs, organ systems, and the entire individual.

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-16 net votes
10 up votes
26 down votes
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(@chuck.sanders)

Goal 2: Reduce Human Disease

Bringing Personalized Biochemistry and Biophysics to Bear on Problems of Personalized Heart, Lung and Blood Medicine

Precision medicine will provide unprecedented opportunities to tailor health care based on knowledge of personal patterns of genetic variations. These variations usually impact protein or RNA sequences, resulting in altered properties. These alterations can result in increased susceptibility to a particular disease or intolerance to common therapeutics. To take full advantage of knowing a patient’s set of gene variations,... more »

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-2 net votes
9 up votes
11 down votes
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(@greg.martin)

Goal 2: Reduce Human Disease

Novel methods to diagnose and treat microvascular ischemia

Microvascular ischemia is common, particularly in the setting of critical illness. We need better ways to evaluate, diagnose and treat these conditions, whether they relate to microvascular myocardial ischemia, as a primary diagnosis of complication of other acute illness, or non-myocardial ischemia during the course of surgery, injury, infection or acute illness.

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0 net votes
2 up votes
2 down votes
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(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Human normal variation and resilience across lifespan

What is the measureable normal human variation at the -omic, cellular, organ, and system levels within the population and across the lifespan?
• What are the range of normal human cellular functions that create resilience at all levels—cells, organs, organ systems?
• What inter-organ, tissue, and cellular communications maintain individual health and the health of populations?
• How do we understand why individuals with... more »

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19 net votes
26 up votes
7 down votes
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(@nhlbiforumadministrator1)

Goal 2: Reduce Human Disease

The effects of environmental factors on heart, lung, blood, sleep disease development across the lifespan

How do growth, development, exposure, and behavior affect heart, lung, blood, sleep disease development and outcome throughout the lifespan?

 

How do you improve organ function/capacity during childhood?

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12 net votes
32 up votes
20 down votes
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(@dcz000)

Goal 4: Develop Workforce and Resources

Training approaches in lymphatic biology

The lymphatic vascular network connects the parenchymal interstitium through the nodes to the veins. Lymph serves as the transport pathway between these compartments and via its flow, controls interstitial fluid, macromolecular exchange, lipid absorption, immune cell trafficking and is critical to edema prevention/resolution, lipid metabolism, inflammation and immunity. Knowledge of this vascular network lags far behind... more »

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12 net votes
13 up votes
1 down votes
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(@apollia112)

Goal 1: Promote Human Health

Do our modern "traditional" sleep schedules defy nature?

Here's an interesting article which shows that the modern tradition of eight hours of unbroken sleep might actually be unnatural, and quite different from what our ancestors typically did:

http://www.bbc.com/news/magazine-16964783

So, maybe the majority of our modern societies (even the people without recognized sleep disorders) are unwisely fighting against biology?

Perhaps a lot of people's health issues, such as... more »

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5 net votes
23 up votes
18 down votes
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(@greg.martin)

Goal 2: Reduce Human Disease

Vascular biology and the pathophysiology of sepsis

Unravel the cellular & molecular mechanisms related to the vascular biology of sepsis and related cardiovascular collapse. The goal is to develop a new scientific framework for the prevention of sepsis related morbidity and mortality by applying novel approaches to discover new targets for biomarkers and therapy by promoting multidisciplinary research required for scientific cross-talk between complementary research disciplines... more »

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4 net votes
8 up votes
4 down votes
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