Showing 85 ideas for tag "heart"
(@chenx106) kudos icon +

Goal 2: Reduce Human Disease

Impact of lung remodeling on congestive heart failure progression

End stage congestive heart failure (CHF) causes intensive lung remodeling beyond the type-2 pulmonary hypertension. CHF induced lung remodeling includes profound lung fibrosis, lung vascular remodeling and lung inflammation. Understanding CHF-induced lung remodeling is also critical to understand the right ventricular failure. However, this area is largely unstudied. Regulating CHF-induced lung remodeling and the underlying... more »

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13 net votes
15 up votes
2 down votes
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(@yuri.astrakhan) kudos icon +

Goal 2: Reduce Human Disease

How to organize artificial pulsatile propelling of blood maintaining the balanced circulation?

Venous pressure, being very low, distends (deforms) the ventricle - but due to elastic or viscous law of deformation? Elastic deformation depends on stress (pressure) only and the viscous one - on stress and time. When pressures are low you can't get large distention due to stress only (time-independent) unlike the case when you apply low stress and long time interval. If we want to use venous pressure as one of regulators... more »

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-9 net votes
2 up votes
11 down votes
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(@aabbate) kudos icon +

Goal 2: Reduce Human Disease

Modulation of cardiac contraction and relaxation in heart failure: role of systemic inflammation

Is cardiac contraction and relaxation in heart failure modulated by the systemic inflammatory response?

There is overwhelming evidence that inflammatory biomarkers predict worse outcome in acute and chronic heart failure.

Despite the wealth of evidence, clinical trials in this area have either not been completed, failed, or provided inconclusive results.

The questions that remain are:
1) Is inflammation a mechanism... more »

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8 net votes
14 up votes
6 down votes
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(@xuejunparsons) kudos icon +

Goal 3: Advance Translational Research

Exploring Future Cardiovascular Medicine: Heart Precursors Directed from Human Embryonic Stem Cells for Myocardium Regeneration

Cardiovascular disease (CVD) is a major health problem and the leading cause of death in the Western world. Currently, there is no treatment option or compound drug of molecular entity that can change the prognosis of CVD.

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-19 net votes
9 up votes
28 down votes
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(@abasit88) kudos icon +

Goal 1: Promote Human Health

Coordination for Cardiac Care: Centalized database and joint sessions

Most senior citizens see a number of doctors. Mostly, coordination among the physicians is limited. Less than perfect to say the least.

Why all the physicians taking care of a patient don't maintain a common central database as well as meet with the patient together- say once a year.

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1 net vote
3 up votes
2 down votes
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(@kullerl) kudos icon +

Goal 2: Reduce Human Disease

What are the Determinants of Short Term Prediction of Heart Attacks?

In spite of many years of research, we still cannot predict the short term risk of a heart attack or sudden CHD death. Most CHD deaths occur outside of the hospital. In spite of improvement of out-of-hospital emergency care, most “sudden death events” are still not successfully resuscitated.

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-12 net votes
7 up votes
19 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 2: Reduce Human Disease

A Program of Research in the Prevention of Chronic Heart Failure

There is a need to improve identification and surveillance of persons at risk for heart failure and pathological ventricular remodeling prior to development of clinically overt heart failure.

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14 net votes
28 up votes
14 down votes
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(@nhlbiforumadministrator1) kudos icon +

Goal 3: Advance Translational Research

Risk Mitigation of Implantable Cardiovascular Devices

There is a serious need to improve implantable cardiovascular devices to eliminate, or at least substantially reduce, the risk of serious adverse events from occurring to more effectively treat patients.

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-14 net votes
9 up votes
23 down votes
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(@nhlbiforumadministrator) kudos icon +

Goal 2: Reduce Human Disease

Heart transplant surveillance

It is essential to develop clinically viable, non-invasive, less expensive technologies for the surveillance of allograft rejection in heart transplant patients. Critical challenges that exist in the near term or long term surveillance after transplant is the unavailability of molecular and cellular level markers that can be non-invasively imaged and quantified detect rejection and thus improve patient survival. Development... more »

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1 net vote
14 up votes
13 down votes
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