Showing 77 ideas for tag "lung"
(@nhlbiforumadministrator)

Goal 2: Reduce Human Disease

Pulmonary Vascular Diseases

Does treatment with spironolactone improve outcomes in patients with pulmonary arterial hypertension (and/or pulmonary hypertension associated with diffuse parenchymal lung disease or COPD)?

Spironolactone has been shown beneficial in CHF and many of the same mechanisms are at plan in RV failure from pulmonary hypertension.

Again, no clear evidence whether this is a useful treatment or not, and no evidence to guide... more »

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(@gcosgrove)

Goal 2: Reduce Human Disease

Fibrosis Care Center Network and Patient Registry

Complex diseases such as interstitial lung disease and pulmonary fibrosis requires a collaborative effort to effectively characterize, appropriately diagnose, and efficient evaluate novel therapies. Similarly, basic, translational and clinical research in this field requires the integration of clinical phenotypes with biologic specimens. We propose the expanded development of the Care Center Network and Patient Registry... more »

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(@john.alcorn)

Goal 2: Reduce Human Disease

Impact of Successive Acute Lung Injury on Subsequent Challenge

A great deal of focus has been placed on understanding chronic lung diseases such as asthma and CF. Long term changes in inflammatory and epithelial processes are well documented in this area. However, less research has addressed the impact of successive pulmonary injuries and how these seemingly acute events shape the lung response. This is the crux of the multi-hit theory regarding interstitial lung disease. Many acute... more »

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(@akuaban)

Goal 2: Reduce Human Disease

Optimization of Existing Therapies for Sickle Cell Disease

How can the safety, dosing and benefits of existing therapies for sickle cell disease such as hydroxyurea, be optimized in order to increase its efficacy and improve patient adherence?

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