Showing 39 ideas for tag "obesity"
(@nhlbiforumadministrator1) kudos icon +

Goal 2: Reduce Human Disease

A Systems Approach to Obesity

There is a need to use an integrated systems approach to obesity prevention and treatment. Obesity is a complex phenotype influenced by factors from the molecular to the socio-economic level. To address the causes and prevention of obesity, we need to integrate information at the molecular level with behavioral, social and environmental data. This will require investigators in molecular biology, genetics, epidemiology,... more »

Voting

97 net votes
138 up votes
41 down votes
Active
(@skumanyi) kudos icon +

Goal 4: Develop Workforce and Resources

Research training to support population-focused obesity research in ethnic minority populations

NIH is already facing a challenge in increasing the number and viability of researchers of color. Obesity research in black (or other high risk minority) populations can be used to explore how research training programs that focus on specific issues of importance to populations of color might contribute to the recruitment and success of ethnic minority researchers in the NIH system.

Voting

6 net votes
6 up votes
0 down votes
Active
(@nhlbiforumadministrator) kudos icon +

Goal 3: Advance Translational Research

Move toward more probative research

As some of us described in a recent publication, in the fields of nutrition and obesity, and perhaps in other fields as well, there is often a great deal of research which uses up resources, investigator time, journal pages, and attention span for questions that do not advance the field. We call for scientists, reviewers, and funding decision makers to collectively ask much more rigorously, "How will this proposed study... more »

Voting

1 net vote
2 up votes
1 down votes
Active
(@rpate0) kudos icon +

Goal 1: Promote Human Health

Prevention of Obesity

What are the behavioral factors that predispose to excessive weight gain and development of obesity? And, which intervention strategies can effectively prevent excessive weight gain and obesity? NHLBI, other NIH institutes and the society at-large have invested heavily in research and clinical practice aimed at treatment of obesity (i.e, weight loss in those who are already overweight). However, much less research... more »

Voting

6 net votes
8 up votes
2 down votes
Active
(@popkin) kudos icon +

Goal 1: Promote Human Health

Evaluation of large-scale regulatory efforts in the US and elsewhere

A number of cities(e.g Berkeley), states and countries (e.g Mexico's SSB tax, Chiles SSB and soon marketing controls and food package front of package label) will go into effect. Rigorous evaluations of the efforts will provide some sense of their potential to effect food purchase and dietary pattern and ultimately cardiometaboiic changes. Serious rigorous independent evaluations are needed to learn if these options--pushed... more »

Voting

22 net votes
42 up votes
20 down votes
Active
(@dsd110) kudos icon +

Goal 1: Promote Human Health

Individually-Tailored Approaches to Manage Perinatal Weight Gain to Improve Maternal and Infant Health

Managing perinatal weight gain is a major challenge in research and practice. More women enter pregnancy already overweight or obese which increases the risks for morbidity and mortality for both mother and baby. Novel strategies are needed to effectively manage weight gain in this population. This may include infusing engineering principles and dynamical modeling to better understand the complex interactions of biological... more »

Voting

24 net votes
34 up votes
10 down votes
Active
(@rwing0) kudos icon +

Goal 2: Reduce Human Disease

Developing approaches to the dissemination of behavioral weight loss programs

The Challenge is to make behavioral weight loss programs readily available to he many overweight and obese patients who need them. Behaivoral weight loss programs are effective in producing weight losses of 7-10% of initial body weight, which has been shown to have major beneficial effects on a number of diseases relevant to NHLBI--including hypertension and sleep apnea. However, at present, these programs are not widely... more »

Voting

3 net votes
17 up votes
14 down votes
Active
(@nhlbiforumadministrator) kudos icon +

Goal 2: Reduce Human Disease

Using Genomics to Predict Response to Weight Loss Interventions

Weight loss in response to interventions (both short term and long term maintenance) varies widely between individuals. What is the optimal use of the current molecular arsenal (genomics, metabolomics, expression arrays, etc.) to accurately predict individuals that will respond favorably to specific weight loss strategies?

Voting

0 net votes
27 up votes
27 down votes
Active
(@kerstilinask) kudos icon +

Goal 2: Reduce Human Disease

Environmental induction of congenital heart defects and finding means of prevention

Congenital heart defects (CHDs) continue to be the leading cause of death among all infants with birth defects. It is reported that approximately 10% of cardiac congenital anomalies have a genetic basis. An equal percentage, or ~10%, is due to environmental factors. For ~60% the etiology is unknown and considered to have a multifactorial basis, eg, environmental agents having a role against a specific genetic background,... more »

Voting

-7 net votes
16 up votes
23 down votes
Active
(@nhlbiforumadministrator) kudos icon +

Goal 4: Develop Workforce and Resources

Increased methods training for investigators

It is clear that there are concerns about reproducibility and quality control in science in general and in obesity-related research in particular. Increased opportunities for training in rigorous scientific practices for obesity researchers and biomedical and behavioral researchers in general may be helpful to increase rigor and reproducibility.

Voting

2 net votes
2 up votes
0 down votes
Active
(@victor.j.stevens) kudos icon +

Goal 1: Promote Human Health

dose-response relationship for behavioral treatment of obesity

As a member of the NHLBI panel updating the obesity treatment guidelines, it was clear that there has not been much systematic work on the relationship between the frequency of intervention contacts and the short and long-term effects on weight change and maintenance of weight change. The general finding that more frequent contacts with professional weight loss counselors, and a longer series of contacts, are more effective,... more »

Voting

-2 net votes
3 up votes
5 down votes
Active