So, maybe the majority of our modern societies (even the people without recognized sleep disorders) are unwisely fighting against biology?
Perhaps a lot of people's health issues, such as... more »
Studies in different subjects have shown that there are major individual differences in response to sleep loss and circadian disruption. Twin studies have shown that this is heritable. There needs to be an intensive effort to assess basis of these individual differences. This could include in-depth phenotyping studies, e.g., neuroimaging, genetic studies, “-omic” studies, epigenetic changes, etc.
Data indicate the association between short sleep and circadian disruption on a number of adverse outcomes such as cardiovascular disease, metabolic disorders, hypertension, etc. There is a need to move beyond association to interventions that can be shown to improve sleep duration and circadian disruption.
Does the homeostasis and health of the lung depend on circadian-coupled genomic function?