(@eastcastlegeastcastle007) kudos icon +

Goal 2: Reduce Human Disease

Single thing needed to prevent obesity: control the mouth

The cause of obesity is clear and simple: eating > needs, or in > out; that is, energy intake is greater than energy use. For the majority of the public, there is little genetic component to cause obesity or over weight. Rather, personal determination is the single thing that is needed to control body weight. Just control the mouth. Simple and easy, and free. Even for the most favorite food, the amount to eat should be... more »

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11 up votes
93 down votes
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(@alexandercan.aw) kudos icon +

Goal 2: Reduce Human Disease

Condom with Retention Means And Shield (Patent Pending)

Condom designed to protect a males pubic areas and scrotum, fingers and hands from coming in contact with infectious fluids. The adoption of a shield to reduce the occurrence of HPV and other STI infections. This is the first and only condom in the world that uses a latex shield which is designed to protect a promiscuous males fingers and hands from HPV and other infectious human secretions that may be in fluids,. We... more »

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-43 net votes
1 up votes
44 down votes
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Goal 2: Reduce Human Disease

Cardiovascular dysfunction in geriatric trauma patients

There is too little research funding addressing cardiovascular dysfunction in geriatric trauma patients. There have been little interest in funding this work. Yet, the geriatric population is growing.



Geriatric trauma patients are predominantly women.



Historically, the trauma societies provide guidance for diagnosis and treatment of severe trauma. However, "trauma guidance" historically was the same for children,... more »

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-31 net votes
1 up votes
32 down votes
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(@lekurlandsky) kudos icon +

Goal 2: Reduce Human Disease

Can transcutaneous carboxyhemoglobin measure endogenous heme oxygenase activity?

Non-invasive measurement of transcutaneous carboxyhemoglobin (SpCO) by CO-oximetry has been shown to reflect disease activity in asthma, allergic rhinitis, Staphylococcal pneumonia/sepsis and to correlate positively with lung function in cystic fibrosis. Given published studies of heme oxygenase activity in these diseases as a reflection of oxidant or inflammatory activity, does measurement of SpCO reflect endogenous... more »

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-24 net votes
1 up votes
25 down votes
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Goal 2: Reduce Human Disease

A parasite?

We know Alzheimer’s Disease, Parkinson’s Disease and Luey Body Dementia are all related. Could it be they are all caused by a parasite (Luey bodies) that gives different symptoms depending on the area of the brain they infest? They would be electrically active and shorting out different parts of the brain. They might also be transmissible through intimate contact between human beings.

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-24 net votes
3 up votes
27 down votes
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Goal 2: Reduce Human Disease

Basic Research for HIV/AIDS and HLB Health and Diseases

What HIV/AIDS-related basic research can NHLBI support in the next 5-10 years to investigate the fundamental mechanisms of HIV-related heart, lung, and/or blood (HLB) diseases alone and in the context of antiretroviral therapy (ART) to improve heart, lung, and blood health outcomes in HIV infections as well as the fundamental mechanisms of hematopoietic stem cell transplantation in potential elimination or eradication... more »

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-22 net votes
14 up votes
36 down votes
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Goal 2: Reduce Human Disease

Can Tai Chi Chuan Improve Osteoporosis?

Tai chi chuan, a slow-moving ancient form of martial art, is one of the fastest growing exercises today. People of all ages are learning it for a wide variety of reasons. The main reason seniors are learning tai chi is for the health-building effects.

Osteoporosis is a common problem suffered by many seniors. I challenge NHLBI to research if and how osteoporosis is actually improved by a consistent and long-term... more »

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-20 net votes
6 up votes
26 down votes
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Goal 2: Reduce Human Disease

Patient-Specific Blueprints to Guide Cardiac Surgery

In order to increase the success of robotic mitral valve repair, we need to stimulate a fusion of multi-modal functional imaging with 3-D valve models that can accurately predict valve shape and closure throughout the cardiac cycle, then develop surgical “blueprints” that overlay incision and suture maps on the surgeon’s console to guide perioperative robotic repair.

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-19 net votes
6 up votes
25 down votes
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Goal 2: Reduce Human Disease

Clinical Research for HIV/AIDS and HLB Health and Diseases

What HIV/AIDS-related clinical research can NHLBI support in the next 5-10 years on the prevention, diagnosis, and treatment of HIV-related heart, lung, and/or blood (HLB) diseases in adults and children to improve heart, lung, and blood health outcomes in HIV infections?

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-19 net votes
14 up votes
33 down votes
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Goal 2: Reduce Human Disease

Gene Therapies to Revitalize/Regenerate Cardiac Function

There is a need to examine the use of recombinant DNA to the heart for correction of genetic abnormalities or restoration of normal signaling pathways to prevent heart failure. However, gene therapy is a complex process and more studies are needed in which tissue targeting, route of delivery, regulation of target gene expression, therapeutic dose, and identification of robust biomarkers are further investigated.

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-18 net votes
8 up votes
26 down votes
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Goal 2: Reduce Human Disease

Randomized trial of low carbohydrate high fat dietary pattern

There is a need for a large, simple, hard outcome trial of dietary advice to measure the effects of lowering simple carbohydrates versus lowering unhealthy fats. The main challenge will be to overcome bias favoring the more conventional dietary approach.

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5 up votes
22 down votes
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