Thank you for participating!

Thank you to all who contributed to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. Ultimately, over 1,000 ideas were submitted, with more than 42,000 votes. This remarkable response exceeded expectations and provided a wealth of ideas to draw upon as NHLBI moves forward. Please visit the NHLBI Strategic Visioning page to find out more about the NHLBI Strategic Visioning process.


Welcome to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. The Institute is gathering ideas for the most compelling scientific priorities in the four NHLBI Strategic Goals to address over the next decade.

(@tcooper)

Goal 2: Reduce Human Disease

The relationship between genetic variation and disease mechanisms

What is the contribution of individual differences in RNA processing to disease causation, disease modification, disease susceptibility, and positive or negative responses to therapies? Studies using genome sequencing combined with RNA-seq have determined that genetic variation affects regulation of RNA processing as frequently as transcriptional regulation. While transcriptional networks are well defined in heart development... more »

Voting

19 net votes
24 up votes
5 down votes
Active
(@dayam0)

Goal 2: Reduce Human Disease

Benefits of intraosseous access on outcomes from OHCA

Vascular access is a challenge in the setting of out-of-hospital cardiac arrest (OHCA). The failure of medications to impact outcomes may be in part related to the delay in drug delivery from the IV route. EMS systems have adopted intraosseous (IO) access but it is not clear if these are affecting outcome and there has been no large RCT. The current IO access devices are expensive and use different routes (sternal, tibia,... more »

Voting

0 net votes
2 up votes
2 down votes
Active
(@cjoseph)

Goal 2: Reduce Human Disease

Consequences of ABO or Rh Type Specific versus Non-Type Specific Platelet Transfusions

What are the consequences, clinically and immunologically, of ABO or Rh type specific vs. non-type specific platelet transfusions? There is widely varying practice as to ABO and Rh matching of platelets for transfusion. Most studies demonstrate that use of ABO unmatched (non-identical) platelets are associated with increased 1) platelet refractoriness (small randomized trials), 2) red cell transfusion needs and hemolysis,... more »

Voting

-4 net votes
25 up votes
29 down votes
Active
(@nhlbiforumadministrator)

Goal 2: Reduce Human Disease

Spirometry for diagnosis and treatment of COPD

1. What is the comparative effectiveness of different approaches to implementing use of spirometry in primary care to confirm the diagnosis of COPD (e.g., increased reimbursements, use of EMRs and other tools)
2. What is the comparative effectiveness of using symptoms vs. spirometry in increasing patient and adherence to COPD treatment guidelines?
3. What is the comparative effectiveness of using a fixed FEV1/FVC ratio... more »

Voting

2 net votes
2 up votes
0 down votes
Active
(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Paracrine Signaling in the Heart

We need to improve the understanding of the molecular and physiological bases of paracrine signaling of heart, and use the knowledge gained to develop improved, effective approaches to diagnose, treat, and prevent cardiac disorders.

Voting

13 net votes
27 up votes
14 down votes
Active
(@treva0)

Goal 4: Develop Workforce and Resources

Training Support for Non-Research-Intensive Institutions

Institutions that are less research intensive, which may characterize some of the Historically Black Colleges and Universities, Hispanic Serving Institutions and tribal institutions with primarily minority faculty and/or student body, may need additional support for training researchers and for performing both hypothesis driven and student integrated research to provide an environment conducive with NIH efforts to enhance... more »

Voting

-1 net votes
6 up votes
7 down votes
Active
(@dayam0)

Goal 4: Develop Workforce and Resources

Development of IT tools to rapidly access key portions of the EHR

As the volume of information in EHR has continued to increase, one of the current challenges is how to find key pieces of information within the EHR. For example if a patient presents to the ED with Chest Pain as chief complaint, key information for that patient related to this chief complaint should be retrieved by the IT system and presented to the clinician for review such as prior ECG's, prior work-ups including any... more »

Voting

2 net votes
4 up votes
2 down votes
Active
(@coretta.jenerette)

Goal 4: Develop Workforce and Resources

Sickle cell education for healthcare providers

Although sickle cell was first described more than 100 years ago and more than 100,000 individuals in the US are living with sickle cell disease, healthcare providers still lack basic knowledge of the key components in providing care for individuals with sickle cell. This often leads to poor health outcomes including stigmatization of patients with sickle cell seeking care. Evidenced-based curriculum should be available... more »

Voting

18 net votes
21 up votes
3 down votes
Active
(@yanyunw)

Goal 1: Promote Human Health

Study wellness instead of diseases by longitudinal follow-up of frequent and long term blood donors

Blood donors (especially young donors) in general represent healthy populations. Longitudinal follow-up of frequent and long term blood donors can be useful to establish data and sample sources for the study of wellness, instead of disease (especially for blood diseases). Not only it can be used as healthy controls, it can also be used to predict the wellness factors such as genetic variation, life style, exercise patterns,... more »

Voting

2 net votes
2 up votes
0 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Access to healthcare for treatment/management of asthma and allergies, and funding of research on asthma and allergies

It is essential that people with asthma and allergies have access to affordable, quality healthcare for the treatment and management of asthma and allergies, and that research is funded to address prevention, screening, and lifestyle interventions to reduce the incidence and adverse effects of asthma and allergies. These conditions impose significant costs on the overall health care system and on patients and their families.... more »

Voting

1 net vote
1 up votes
0 down votes
Active