Thank you for participating!

Thank you to all who contributed to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. Ultimately, over 1,000 ideas were submitted, with more than 42,000 votes. This remarkable response exceeded expectations and provided a wealth of ideas to draw upon as NHLBI moves forward. Please visit the NHLBI Strategic Visioning page to find out more about the NHLBI Strategic Visioning process.


Welcome to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. The Institute is gathering ideas for the most compelling scientific priorities in the four NHLBI Strategic Goals to address over the next decade.

(@joachim.herz) kudos icon +

Goal 3: Advance Translational Research

Lipid and lipoprotein metabolism in the CNS

The analysis of lipoprotein metabolism has traditionally been restricted to the easily accessible circulation and peripheral tissues. Very little work has been done behind the blood brain barrier, where many of the lipid carrying or metabolizing genes are also expressed. Yet we know very little about their functions there, although for instance ApoE4 is THE primary risk factor for late-onset Alzheimer's disease. Conventional... more »

Voting

-4 net votes
7 up votes
11 down votes
Active
(@htwig0) kudos icon +

Goal 2: Reduce Human Disease

What is the role of chronic inflammation in lung complications in the HAART era?

With the advent of HAART HIV-infected subjects are living longer. Lung infectious complications so common in the early stages of the HIV epidemic have been replaced by those associated with chronic inflammation (COPD, pulmonary hypertension, lung cancer). Furthermore, this chronic inflammation is likely contributing to premature vascular complications (i.e coronary disease) seen in this population. All of these complications... more »

Voting

1 net vote
19 up votes
18 down votes
Active
(@rsackstein) kudos icon +

Goal 3: Advance Translational Research

How can we make cell therapy most effective?

In order to achieve the enormous promise of cell-based therapies (including stem cell-based therapies and adoptive cellular immunotherapies), we need to get the relevant cells to the sites where they are needed. Cell migration is critically dependent on expression of cell surface glycans that mediate adhesion between circulating cells and target tissue endothelial cells. We need to optimize these adhesive interactions... more »

Voting

23 net votes
30 up votes
7 down votes
Active
(@ceci00) kudos icon +

Goal 2: Reduce Human Disease

Understanding Glymphatic Pathways and Waste Clearance abnormalities in brain disease

Cerbrospinal fluid flow and waste clearance through glyphatic pathways are likely to be important in numerous brain diseases including such devastating diseases such as alzheimer's , parkinson's, stroke and migraine. However, relatively little is known about the brain's waste clearance mechanisms, and how failure in these systems may underlie brain disease. Build up of proteins and calcification have been shown to... more »

Voting

3 net votes
3 up votes
0 down votes
Active
(@jennifergrobinson) kudos icon +

Goal 2: Reduce Human Disease

How can we implement what we already know for ASCVD prevention?

We have a number of highly effective evidence-based interventions that have been shown to reduce ASCVD events - statins, BP drugs, aspirin, acute care. Yet large proportions of high risk population groups are not taking evidence-based treatment. Numerous interventions have been tried at multiple levels from the individual patient to the federal government payors. What are the best practices? How can we systematically... more »

Voting

-9 net votes
3 up votes
12 down votes
Active
(@nhlbiforumadministrator) kudos icon +

Goal 4: Develop Workforce and Resources

Improving Biomedical Careers

There is a critical challenge to retain highly trained basic and clinical scientists in the biomedical research enterprise and expediently promote their independence and capacity to produce innovative discoveries. There is a need to provide more funding opportunities for collaborative, team-science approaches to scientific investigation by interdisciplinary teams comprised of clinician scientists, basic researchers, and... more »

Voting

32 net votes
50 up votes
18 down votes
Active
(@nhlbiforumadministrator1) kudos icon +

Goal 1: Promote Human Health

The CRISPER-Cas challenge: Need to re-phenotype KO animals?

Because traditional knock out models and CRISP/Cas models often show different phenotypes for the same gene deletion, do we need to re-phenotype hundreds/thousands of knock out animal models and revisit the conclusions of many studies based on using these animal models? This research may not appear very innovative but may be very important for drawing correct conclusions about gene functions and interactions - should... more »

Voting

-16 net votes
10 up votes
26 down votes
Active
(@teitelbaum) kudos icon +

Goal 4: Develop Workforce and Resources

Predictable and Steady Funding Growth

There is a need for a predictable, steady expansion of funding of NIH. The repetitive booms and busts in research funding are a primary source of the current instability of the biomedical research and training systems. Funding goals should not be simply “more”, or another “doubling”, but instead a trajectory of steady expansion of research funding that can be sustained over the medium-to-long term.

Voting

28 net votes
32 up votes
4 down votes
Active
(@elliott.crouser) kudos icon +

Goal 2: Reduce Human Disease

Improving the Detection and Treatment of Cardiac Sarcoidosis

Sarcoidosis afflicts young adults, particularly African Americans and females, and often causes chronic disability or death. Cardiac sarcoidosis (CS) was once considered to be a rare disease manifestation; however, with the development of improved diagnostic testing procedures, such as MRI and PET scans, CS is now known to afflict up to 40% of sarcoidosis patients and is recognized as a major cause of death. The current... more »

Voting

-4 net votes
2 up votes
6 down votes
Active
(@nhlbiforumadministrator) kudos icon +

Goal 1: Promote Human Health

Functional and high throughput screening assays

There is a need to develop functional assays and high throughput screening to develop probes and potential drug therapies.
A. Functional Assays. Researchers face a challenging gap between identifying many sequence variations of potential interest and recognizing which of these variations have a direct functional effect on the physiological system of interest, as opposed to merely being associated with the actual causal... more »

Voting

-1 net votes
9 up votes
10 down votes
Active